Cat. No.: HY-101195

DL-erythro-Dihydrosphingosine

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DL-erythro-Dihydrosphingosine is a sphingosine-based PKC inhibitor. DL-erythro-Dihydrosphingosine directly inhibits the enzymatic activity of PLA2. DL-erythro-Dihydrosphingosine inhibits the activity of Bcl-2 protein involved in apoptosis. DL-erythro-Dihydrosphingosine inhibits the activity of matrix metalloproteinases (MMP). DL-erythro-Dihydrosphingosine is applicable for research on cancer and inflammatory diseases.

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 3102-56-5
Formula: C₁₈H₃₉NO₂
Molecular Weight:301.52

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

DL-erythro-Dihydrosphingosine Chemical Structure

CAS No.: 3102-56-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PKC Isoforms :

All Phospholipase Isoforms :

All Bcl-2 Family Isoforms :

All MMP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
FL5.12	IC₅₀	3.5 μM Compound: 7	Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis	[PMID: 27475534]
HBL-100	GI₅₀	25 μM Compound: 10d	Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
HeLa	GI₅₀	15 μM Compound: 10d	Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
Jurkat	IC₅₀	3.53 μM Compound: Dihydrosphingosine	Inhibition of wild type human Jurkat cells after 18 hrs by MTT assay Inhibition of wild type human Jurkat cells after 18 hrs by MTT assay	[PMID: 17400555]
Jurkat	IC₅₀	3.68 μM Compound: Dihydrosphingosine	Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR2 mutant cells proliferation after 18 hrs by MTT assay Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR2 mutant cells proliferation after 18 hrs by MTT assay	[PMID: 17400555]
Jurkat	IC₅₀	4.9 μM Compound: Dihydrosphingosine	Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR1 mutant cells proliferation after 18 hrs by MTT assay Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR1 mutant cells proliferation after 18 hrs by MTT assay	[PMID: 17400555]
Jurkat	IC₅₀	6.31 μM Compound: Dihydrosphingosine	Inhibition of human 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR3 mutant cells proliferation after 18 hrs by MTT assay Inhibition of human 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR3 mutant cells proliferation after 18 hrs by MTT assay	[PMID: 17400555]
SW1573	GI₅₀	4.5 μM Compound: 10d	Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
T47D	GI₅₀	22 μM Compound: 10d	Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
WiDr	GI₅₀	19 μM Compound: 10d	Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay	[PMID: 25899335]

In Vitro

DL-erythro-Dihydrosphingosine inhibits the activity of Bcl-2 protein involved in apoptosis, inhibits the activity of matrix metalloproteinases (MMPs)^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3102-56-5
Appearance Solid
Molecular Weight 301.52
Formula C₁₈H₃₉NO₂
Color White to off-white
SMILES

CCCCCCCCCCCCCCC[C@H](O)[C@H](N)CO
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chao R, et al. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992;267(33):23459-23462. [Content Brief]

[2]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004;484(1):9-17. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DL-erythro-Dihydrosphingosine

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

All PKC Isoforms

All Phospholipase Isoforms

All Bcl-2 Family Isoforms

All MMP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DL-erythro-Dihydrosphingosine Related Classifications

HY-101195 Related Classifications