Cat. No.: HY-101259

BMS-195614

(Synonyms: BMS 614)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a K_i of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, AP-1 and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis.

For research use only. We do not sell to patients.

Purity: 99.5%
CAS No.: 182135-66-6
Formula: C₂₉H₂₄N₂O₃
Molecular Weight:448.51

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

BMS-195614 Chemical Structure

CAS No.: 182135-66-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]^[3]^[4]^[5]

BCL2

IL-6

All RAR/RXR Isoforms :

All Bcl-2 Family Isoforms :

All NF-κB Isoforms :

All PPAR Isoforms :

All VEGFR Isoforms :

All Interleukin Related Isoforms :

In Vitro

BMS-195614 (10-20 μM) reduces blue light-induced phototoxicity and modulates inflammation and angiogenesis in the presence of A2E in RPE cells^[2].
BMS-195614 (6 μM, 24 h) reverses the anti-inflammatory effect of Vitamin A (HY-B1342) and RA on the release of IL-6 by LPS-activated BV-2 cells^[3].
BMS-195614 (1 μM, 24 h) inhibits Retinoic acid (HY-14649)induced migration of MC3T3E1 osteoblastlike cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[2]

Cell Line:

RPE cells
Concentration:

10 µM
Incubation Time:
Result:

Inhibited NF-κB transactivation, the transactivation of AP-1, the expression of IL-6 and VEGF mRNA.

In Vivo

BMS-195614 (2-10 mg/kg, p.o., 7 days) results in minimal or no inhibition of overall spermatogenesis in mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 182135-66-6
Appearance Solid
Molecular Weight 448.51
Formula C₂₉H₂₄N₂O₃
Color White to off-white
SMILES

O=C(O)C1=CC=C(NC(C2=CC=C3C(C)(C)CC=C(C4=CC5=CC=CC=C5N=C4)C3=C2)=O)C=C1
Synonyms

BMS 614
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Stem Cell Reports

Signaling pathway-based culture condition improves differentiation potential of canine induced pluripotent stem cells. [Abstract]

2025 Sep 18:102640. PMID: 40972586
Vet Sci

Inhibition of Retinoic Acid Receptor Gamma Improves Bovine Embryo Development. [Abstract]

2025 Sep 24;12(10):924. PMID: 41150070
bioRxiv

2026 Jan 23.

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (66.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2296 mL

11.1480 mL

22.2960 mL

5 mM

0.4459 mL

2.2296 mL

4.4592 mL

10 mM

0.2230 mL

1.1148 mL

2.2296 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Géhin M, et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol. 1999;6(8):519-529. [Content Brief]

[2]. Fontaine V, et al. RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation. Int J Mol Sci. 2024 Mar 6;25(5):3037. [Content Brief]

[3]. Kurtys E, et al. The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia. Neurochem Int. 2016 Oct;99:206-214. [Content Brief]

[4]. Inubushi M, et al. Retinoic acid promotes migration of MC3T3‐E1 osteoblast‐like cells via RARα signaling‐mediated upregulation of profilin‐1 expression. Journal of Osaka Dental University, 2019, 53(2): 149-156.

[5]. Chung SS, et al. Pharmacological activity of retinoic acid receptor alpha-selective antagonists in vitro and in vivo. ACS Med Chem Lett. 2013 May 9;4(5):446-450. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2296 mL	11.1480 mL	22.2960 mL	55.7401 mL
	5 mM	0.4459 mL	2.2296 mL	4.4592 mL	11.1480 mL
	10 mM	0.2230 mL	1.1148 mL	2.2296 mL	5.5740 mL
	15 mM	0.1486 mL	0.7432 mL	1.4864 mL	3.7160 mL
	20 mM	0.1115 mL	0.5574 mL	1.1148 mL	2.7870 mL
	25 mM	0.0892 mL	0.4459 mL	0.8918 mL	2.2296 mL
	30 mM	0.0743 mL	0.3716 mL	0.7432 mL	1.8580 mL
	40 mM	0.0557 mL	0.2787 mL	0.5574 mL	1.3935 mL
	50 mM	0.0446 mL	0.2230 mL	0.4459 mL	1.1148 mL
	60 mM	0.0372 mL	0.1858 mL	0.3716 mL	0.9290 mL

Keywords

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BMS-195614

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Endocrinology Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Mitochondria-Targeted Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Antidepressant Compound Library

Protein-protein Interaction Inhibitor Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Nuclear Receptor Compound Library

Cancer Stem Cells Compound Library

Heterocyclic Compound Library

Pain-Related Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Mitochondrial Toxicity Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Cytokine Inhibitors Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) BMS-195614

All RAR/RXR Isoforms

All Bcl-2 Family Isoforms

All NF-κB Isoforms

All PPAR Isoforms

All VEGFR Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

BMS-195614 Related Classifications

Cat. No.: HY-101259