Bcl-2 Family
  3. XZ739


Cat. No.: HY-133557 Purity: 99.06%
Handling Instructions

XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis.

For research use only. We do not sell to patients.

XZ739 Chemical Structure

XZ739 Chemical Structure

CAS No. : 2365172-19-4

Size Price Stock Quantity
5 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All PROTAC Isoform Specific Products:

View All Bcl-2 Family Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

IC50 & Target[1]


2.5 nM (DC50)



In Vitro

XZ739 (0.001-10 μM; 48 hours) potently reduces the viability of T-ALL MOLT-4, B-ALL RS4; 11, SCLC NCI-H146 cells, and platelets after 48 h treatment with IC50s of 10.1, 41.8, 25.3, and 1217 nM, respectively. XZ739 has >100-fold selectivity for MOLT-4 cells over human platelets[1].
XZ739 (1.2-300 nM; 16 hours) induces BCL-XL degradation in MOLT-4 cells[1].
The BCL-XL degradation induced by XZ739 in MOLT-4 is rapid, starting within 2 h; and 8 h after XZ739 treatment, more than 96% of the BCL-XL is degraded with 100 nM of XZ739[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human platelets and MOLT-4 cells
Concentration: 0.001, 0.01, 0.1, 1, and 10 μM
Incubation Time: 48 hours
Result: IC50 values were 10.1 nM and 1217 nM for MOLT-4 cells and platelets, respectively.

Western Blot Analysis[1]

Cell Line: MOLT-4 cells
Concentration: 1.2, 3.7, 11, 33, 100, 300 nM
Incubation Time: 16 hours
Result: Dose-dependently induced BCL-XL degradation.
Molecular Weight







O=C(C1=CC=C(N2CCN(CC3=C(C4=CC=C(Cl)C=C4)CCC(C)(C)C3)CC2)C=C1)NS(C5=CC(S(=O)(C(F)(F)F)=O)=C(N[[email protected]@H](CSC6=CC=CC=C6)CCN(C)CCOCCOCCOCCNC7=C8C(C(N(C9CCC(NC9=O)=O)C8=O)=O)=CC=C7)C=C5)(=O)=O


Room temperature in continental US; may vary elsewhere.


-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (14.81 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7407 mL 3.7037 mL 7.4075 mL
5 mM 0.1481 mL 0.7407 mL 1.4815 mL
10 mM 0.0741 mL 0.3704 mL 0.7407 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2 mg/mL (1.48 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.

Purity: 99.06%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


XZ739XZ 739XZ-739PROTACBcl-2 FamilyApoptosisProteolysis-targeting chimeraCRBNMOLT-4PlateletDegradationB-ALLRS411SCLCNCI–H146H146Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name



Applicant Name *


Email address *

Phone number *


Organization name *

Department *


Requested quantity *

Country or Region *



Bulk Inquiry

Inquiry Information

Product Name:
Cat. No.:
MCE Japan Authorized Agent: