1. Apoptosis
  2. Bcl-2 Family
    Apoptosis
  3. S65487 sulfate

S65487 sulfate (Synonyms: VOB560 sulfate)

Cat. No.: HY-138697A
Handling Instructions

S65487 (VOB560) sulfate is a potent and selective Bcl-2 inhibitor. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities.

For research use only. We do not sell to patients.

S65487 sulfate Chemical Structure

S65487 sulfate Chemical Structure

CAS No. : 2416937-01-2

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Description

S65487 (VOB560) sulfate is a potent and selective Bcl-2 inhibitor. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities[1][2].

In Vitro

S65487 binds to the BH3 hydrophobic groove of BCL-2. S65487 induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC50s in the low nM range[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

S65487 induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat are observed at well tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor, S64315/MIK665[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

815.33

Formula

C₄₁H₄₃ClN₆O₈S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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S65487 sulfate
Cat. No.:
HY-138697A
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