Bcl-2-IN-11
Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia.
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- No. CAS: 2760536-88-5
- Fòrmula: C45H49ClFN7O8S
- Peso molecular:902.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Bcl-2 0.9 nM (IC50) |
Bcl-xL >1000 nM (IC50) |
Bcl-2-IN-11 (compound 6) inhibits the proliferation of RS4;11 acute lymphocyte cells, with an IC50 of 2.37 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2760536-88-5
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Peso molecular 902.43
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Fòrmula C45H49ClFN7O8S
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SMILES
O=S(NC(C(C=CC(N1C[C@H](N(CC1)CC2=C(C3=CC=C(C=C3)Cl)CC(C)(CC2)C)C)=C4)=C4OC5=CN=C(NC=C6)C6=C5)=O)(C7=CC([N+]([O-])=O)=C(C(F)=C7)NC[C@H]8COCCO8)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bcl-2-IN-11 Related Classifications
HY-153953 Related Classifications
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