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Cat. No.: HY-116204

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SKLB70326

SKLB70326 is a small molecule inhibitor of cell cycle progression that induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. SKLB70326 is involved in downregulating cyclin-dependent kinase (CDK) 2, CDK4, and CDK6, while also activating PARP, caspase-3, caspase-9, and Bax, and downregulating Bcl-2.

For research use only. We do not sell to patients.

CAS No.: 1257317-77-3
Formula: C₁₅H₁₃N₃O₂S
Molecular Weight:299.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SKLB70326 Chemical Structure

CAS No.: 1257317-77-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Classifications
Bioz

Biological Activity

Description

All Caspase Isoforms :

All Bcl-2 Family Isoforms :

All CDK Isoforms :

All PARP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	>100 μM Compound: 1g	Cytotoxicity against human A431 cells after 48 hrs by MTT assay Cytotoxicity against human A431 cells after 48 hrs by MTT assay	[PMID: 20846862]
A549	IC₅₀	>100 μM Compound: 1g	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 20846862]
Bel-7402	IC₅₀	7.4 μM Compound: 1g	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay	[PMID: 20846862]
HCT-116	IC₅₀	>100 μM Compound: 1g	Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 20846862]
HepG2	IC₅₀	0.016 μM Compound: 1g	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 20846862]
Huh-7	CC₅₀	<0.4 μM Compound: 13f	Cytotoxicity against human HuH7 cells after 72 hrs by MTT assay Cytotoxicity against human HuH7 cells after 72 hrs by MTT assay	[PMID: 24529869]
Huh-7	EC₅₀	>20 μM Compound: 13f	Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral RNA replication after 72 hrs by luciferase reporter gene assay Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral RNA replication after 72 hrs by luciferase reporter gene assay	[PMID: 24529869]
MCF7	IC₅₀	>100 μM Compound: 1g	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 20846862]
PC-3	IC₅₀	>100 μM Compound: 1g	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 20846862]
RAW264.7	IC₅₀	3.3 μM Compound: 1f	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess assay	[PMID: 23499235]
SMMC-7721	IC₅₀	0.9 μM Compound: 1g	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 20846862]

Chemical Information

CAS No. 1257317-77-3
Molecular Weight 299.35
Formula C₁₅H₁₃N₃O₂S
SMILES

O=C(N)C1=C(C2=CC=C(N=C2S1)C3=CC=CC(OC)=C3)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. SKLB70326, a novel small-molecule inhibitor of cell-cycle progression, induces G₀/G₁ phase arrest and apoptosis in human hepatic carcinoma cells [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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SKLB70326

All Caspase Isoforms

All Bcl-2 Family Isoforms

All CDK Isoforms

All PARP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SKLB70326 Related Classifications

HY-116204 Related Classifications