2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. PARP CDK Bcl-2 Family Caspase Apoptosis
  4. SKLB70326

SKLB70326 is a small molecule inhibitor of cell cycle progression that induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. SKLB70326 is involved in downregulating cyclin-dependent kinase (CDK) 2, CDK4, and CDK6, while also activating PARP, caspase-3, caspase-9, and Bax, and downregulating Bcl-2.

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SKLB70326

SKLB70326 Chemical Structure

CAS No. : 1257317-77-3

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SKLB70326 Related Antibodies

Top Publications Citing Use of Products

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

SKLB70326 is a small molecule inhibitor of cell cycle progression that induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. SKLB70326 is involved in downregulating cyclin-dependent kinase (CDK) 2, CDK4, and CDK6, while also activating PARP, caspase-3, caspase-9, and Bax, and downregulating Bcl-2.

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
> 100 μM
Compound: 1g
Cytotoxicity against human A431 cells after 48 hrs by MTT assay
Cytotoxicity against human A431 cells after 48 hrs by MTT assay
[PMID: 20846862]
A549 IC50
> 100 μM
Compound: 1g
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 20846862]
Bel-7402 IC50
7.4 μM
Compound: 1g
Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
[PMID: 20846862]
HCT-116 IC50
> 100 μM
Compound: 1g
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 20846862]
HepG2 IC50
0.016 μM
Compound: 1g
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 20846862]
Huh-7 CC50
< 0.4 μM
Compound: 13f
Cytotoxicity against human HuH7 cells after 72 hrs by MTT assay
Cytotoxicity against human HuH7 cells after 72 hrs by MTT assay
[PMID: 24529869]
Huh-7 EC50
> 20 μM
Compound: 13f
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral RNA replication after 72 hrs by luciferase reporter gene assay
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral RNA replication after 72 hrs by luciferase reporter gene assay
[PMID: 24529869]
MCF7 IC50
> 100 μM
Compound: 1g
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 20846862]
PC-3 IC50
> 100 μM
Compound: 1g
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
[PMID: 20846862]
RAW264.7 IC50
3.3 μM
Compound: 1f
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess assay
[PMID: 23499235]
SMMC-7721 IC50
0.9 μM
Compound: 1g
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
[PMID: 20846862]
Molecular Weight

299.35

Formula

C15H13N3O2S
CAS No.
SMILES

O=C(N)C1=C(C2=CC=C(N=C2S1)C3=CC=CC(OC)=C3)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SKLB70326 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKLB703261257317-77-3SKLB 70326SKLB-70326PARPCDKBcl-2 FamilyCaspaseApoptosispoly ADP ribose polymerase Cyclin dependent kinaseInhibitorinhibitorinhibit

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