1. (-)-Hinesol

(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer.

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(-)-Hinesol Chemical Structure

(-)-Hinesol Chemical Structure

CAS No. : 23811-08-7

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Description

(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer[1].

In Vitro

(-)-Hinesol (0-25 µg/ml; 24, 48 h) shows antiproliferative activity of the A549 and NCI-H1299 cells in a dose- and time-dependent manner[1].
(-)-Hinesol (0, 2, 8 µg/ml; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase with increases the expression of Bax and decreases the expression of Bcl-2 and cyclin D1[1].
(-)-Hinesol (0, 2, 8 µg/ml; 24 h) decreases the expression of phosphor-ERK1/2, phosphor-MEK1/2, phosphor-IκBα and -p65 level, and shows no change for the total protein levels of IκBα and p65 in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: A549, NCI-H1299 cells
Concentration: 0-25 µg/ml
Incubation Time: 24, 48 h
Result: Inhibited the proliferation of the A549 and NCI-H1299 cells in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0, 2, 8 µg/ml
Incubation Time: 24 h
Result: Induced apoptosis with the apoptotic cells was increased to 21.2 ± 0.96% and 36 ± 1.04% after treatment with hinesol at 2 and 8 μg/mL, respectively.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0, 2, 8 µg/ml
Incubation Time: 24 h
Result: Increased the protein expression of Bax and decreased the expression of Bcl-2.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 0, 2, 8 µg/ml
Incubation Time: 24 h
Result: Showed concentration-dependent increase in the percentage of cell in the G0/G1 phase, and a decrease of the percentage in G2/M phase.
Molecular Weight

222.37

Formula

C15H26O

CAS No.
SMILES

C[C@@H]1[C@]2(C[C@H](C(O)(C)C)CC2)C(C)=CCC1

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Product Name:
(-)-Hinesol
Cat. No.:
HY-N1930
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