23811-08-7
Chemical Structure
(-)-Hinesol
Synonym(s): Hinesol
- CAS No.: 23811-08-7
- Formula:C15H26O
- Molecular Weight:222.37
IUPAC Name: 2-((2R,5S,10S)-6,10-dimethylspiro[4.5]dec-6-en-2-yl)propan-2-ol
InChIKey: ICWHTQRTTHCUHW-GZBFAFLISA-N
SMILES: C[C@@H]1[C@]2(C[C@H](C(O)(C)C)CC2)C(C)=CCC1
Biological Activity: (-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer[1].
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(-)-Hinesol | 98.7% | (-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer. | ||||||||||||||||||||
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- [1]. Guo W, et al. The antitumor effect of hinesol, extract from Atractylodes lancea (Thunb.) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF-κB pathway in non-small cell lung cancer cell lines A549 and NCI-H1299. J Cell Biochem. 2019 Nov;120(11):18600-18607. [Content Brief]
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