Guaiol (Standard)
Guaiol (Standard) is the analytical standard of Guaiol. This product is intended for research and analytical applications. Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions[4]
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 489-86-1
- Formule: C15H26O
- Masse moléculaire:222.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 489-86-1
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Masse moléculaire 222.37
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Formule C15H26O
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SMILES
C[C@@H]1C2=C([C@H](CC[C@@H](C(C)(O)C)C2)C)CC1
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Synonyms
Champacol (Standard); Guaiac alcohol (Standard)
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Yang, Q, et al. (−)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer Oncotarget. 2016 Sep 20;7(38):62585-62597. [Content Brief]
[2]. Ali, A., Tabanca, et al. Chemical composition and biological activity of four salvia essential oils and individual compounds against two species of mosquitoes J. Agric. Food Chem. 63(2), 447-456 (2015). [Content Brief]
[3]. Liu, T, et al. Guaiol - a naturally occurring insecticidal sesquiterpene Nat. Prod. Commun. 8(10), 1353-1354 (2013). [Content Brief]
[4]. Garcia M C F, et al. The in vitro antileishmanial activity of essential oil from Aloysia gratissima and guaiol, its major sesquiterpene against Leishmania amazonensis[J]. Parasitology, 2018, 145(9): 1219-1227. [Content Brief]
[6]. Yang M, et al. Determination and pharmacokinetic study of guaiol in rat plasma by gas chromatography–mass spectrometry with selected ion monitoring[J]. Journal of Chromatography B, 2018, 1085: 30-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Guaiol (Standard) Related Classifications
HY-N3980R Related Classifications
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