GPER/Bcl-2-IN-1
GPER/Bcl-2-IN-1 is a GPER/Bcl-2 inhibitor. GPER/Bcl-2-IN-1 can inhibit the proliferation and neurospheres formation of glioblastoma cells. GPER/Bcl-2-IN-1 can be used for the study of glioblastoma multiforme (GBM).
For research use only. We do not sell to patients.
- Formula: C26H20BrClN2O5S
- Molecular Weight:587.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Bcl-2 |
GPER/Bcl-2-IN-1 (Compound L-37) (0-140 μM, 48 h) exhibits IC50 values of 40.72 μM (LN-18), 39.78 μM (U373), 109.7 μM (BJ), and 23.86 μM (MCF-10A), respectively[1].
GPER/Bcl-2-IN-1 (0-10 μM, 4-5 days) can inhibit the proliferation and neurosphere formation of Gli4 glioblastoma stem cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Gli4 cell
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Concentration:0, 1 and 10 μM
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Incubation Time:5 (in differentiation media) or 4 days (in proliferation media)
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Result:Inhibited the cell viability in differentiation media.
Reduced the cell count in proliferation media with round bottom plates.
Chemical Information
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Molecular Weight 587.87
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Formula C26H20BrClN2O5S
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SMILES
ClC1=CC=C(S(NC(C2=CC=C3C([C@H](C=CC4)[C@H]4[C@H](C5=C(Br)C=C(OCO6)C6=C5)N3)=C2)=O)(=O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPER/Bcl-2-IN-1 Related Classifications
HY-174338 Related Classifications
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