Anticancer agent 306
Anticancer agent 306 is a spiro tetramic acid derivative and a inhibitor of MMP1, MMP7 and PLK1. Anticancer agent 306 exerts antiproliferative activity against H1299, RKO and MCF-7 cells with IC50 values of 19.25 μM, 3.29 μM and 102.36 μM, respectively. Anticancer agent 306 can up-regulate p21 protein and down-regulate CCND1 and CCNB1 proteins to induce cell cycle arrest, regulate the expression of Bcl-2 and Bax to induce cell apoptosis. Anticancer agent 306 can down-regulate MMP1 and MMP7 proteins to inhibit tumor invasion and metastasis. Anticancer agent 306 can be used for the research of lung cancer, colorectal cancer, breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 3043892-01-6
- Formula: C19H21Cl2NO3
- Molecular Weight:382.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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MMP-1 |
MMP-7 |
PLK1 |
Bcl-2 |
Bax |
Caspase 3 |
Caspase 8 |
Anticancer agent 306 (8D) potently inhibits the proliferation of H1299, RKO, and MCF-7 cells with IC50 values of 19.25 μM, 3.29 μM, and 102.36 μM, respectively[1].
Anticancer agent 306 (10-40 μg/mL) dose-dependently down-regulates MMP1, MMP7, PLK1, CCND1, and Bcl-2, and up-regulates p21, Bax, caspase-3, and caspase-8 in H1299 and RKO cells[1].
Anticancer agent 306 (10-40 μg/mL) induces G1-phase cell cycle arrest in H1299 and RKO cells, with a corresponding decrease in S and G2 phase cell proportions[1].
Anticancer agent 306 (10-40 μg/mL) dose-dependently induces early and late apoptosis in H1299 and RKO cells, via the mitochondrial pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3043892-01-6
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Molecular Weight 382.28
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Formula C19H21Cl2NO3
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SMILES
ClC1=CC(Cl)=C(C2=C(OC(CC(C)C)=O)C3(CCCC3)NC2=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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