A-1211212
Based on 1 Customer Validation
A-1211212 (BCL2-IN-1), a chemical probe, is a potent Bcl-2 inhibitor. BCL2-IN-1 binds Bcl-2 with a Ki of <0.01 nM.
For research use only. We do not sell to patients.
- Purity: 98.43%
- CAS No.: 1257044-75-9
- Formula: C47H54ClN7O7S
- Molecular Weight:896.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | EC50 |
>5000 nM
Compound: A-1211212
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Antiproliferative activity against Bcl-xl dependent human MOLT-4 cells assessed as reduction in cell viability by measuring effect concentration by CellTiter-Glo reagent based assay
Antiproliferative activity against Bcl-xl dependent human MOLT-4 cells assessed as reduction in cell viability by measuring effect concentration by CellTiter-Glo reagent based assay
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[PMID: 25787766] |
| MOLT-4 | EC50 |
6 nM
Compound: A-1211212
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Antiproliferative activity against Bcl-2 dependent human MOLT-4 cells assessed as reduction in cell viability by measuring effect concentration by CellTiter-Glo reagent based assay
Antiproliferative activity against Bcl-2 dependent human MOLT-4 cells assessed as reduction in cell viability by measuring effect concentration by CellTiter-Glo reagent based assay
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[PMID: 25787766] |
| MOLT-4 | EC50 |
>5000 nM
Compound: 22
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Antiproliferative activity against human MOLT4 cells in presence of 10% human serum
Antiproliferative activity against human MOLT4 cells in presence of 10% human serum
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[PMID: 28926247] |
| RS4-11 | EC50 |
6 nM
Compound: 22
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Antiproliferative activity against human RS4:11 cells in presence of 10% human serum
Antiproliferative activity against human RS4:11 cells in presence of 10% human serum
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[PMID: 28926247] |
Chemical Information
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CAS No. 1257044-75-9
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Appearance Solid
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Molecular Weight 896.49
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Formula C47H54ClN7O7S
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Color White to yellow
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SMILES
O=C(NS(=O)(C1=CC=C(NC[C@H]2CC[C@H](OC)CC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7
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Synonyms
BCL2-IN-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (111.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1155 mL | 5.5773 mL | 11.1546 mL | 27.8865 mL |
| 5 mM | 0.2231 mL | 1.1155 mL | 2.2309 mL | 5.5773 mL | |
| 10 mM | 0.1115 mL | 0.5577 mL | 1.1155 mL | 2.7887 mL | |
| 15 mM | 0.0744 mL | 0.3718 mL | 0.7436 mL | 1.8591 mL | |
| 20 mM | 0.0558 mL | 0.2789 mL | 0.5577 mL | 1.3943 mL | |
| 25 mM | 0.0446 mL | 0.2231 mL | 0.4462 mL | 1.1155 mL | |
| 30 mM | 0.0372 mL | 0.1859 mL | 0.3718 mL | 0.9296 mL | |
| 40 mM | 0.0279 mL | 0.1394 mL | 0.2789 mL | 0.6972 mL | |
| 50 mM | 0.0223 mL | 0.1115 mL | 0.2231 mL | 0.5577 mL | |
| 60 mM | 0.0186 mL | 0.0930 mL | 0.1859 mL | 0.4648 mL | |
| 80 mM | 0.0139 mL | 0.0697 mL | 0.1394 mL | 0.3486 mL | |
| 100 mM | 0.0112 mL | 0.0558 mL | 0.1115 mL | 0.2789 mL |
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