Carboxymethyl chitosan
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Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma.
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- Reinheit: 90%
- CAS. Nr.: 83512-85-0
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Bax |
Bcl-2 |
Caspase-3 |
Carboxymethyl chitosan (100 μg/mL; 4 days) promotes the proliferation of normal skin fibroblasts but inhibits the proliferation of keloid fibroblasts[1].
Carboxymethyl chitosan hydrogels show enhanced cell migration compared with standard chitosan hydrogels[2].
Carboxymethylated chitosan (50-200 μg/mL; 8 h) increases the viability of Schwann cells exposed to H2O2 and decreases LDH release in a concentration-dependent manner[3].
Carboxymethyl chitosan (0.5-2.0 mg/mL; 24-48 h) significantly inhibits the migration of human umbilical vein endothelial cells (HUVECs)[4].
Carboxymethyl chitosan (50-200 μg/mL; 1 h) inhibits IL-1β-induced apoptosis of rabbit chondrocytes in a dose-dependent manner[5].
Carboxymethyl chitosan (4.0-5.0 mg/mL; 48 h) decreases viability of OS-RC-2, NCI-H1650, and HT-29 cells[6].
Carboxymethyl chitosan (1.0-5.0 mg/mL; 12-24 h) can significantly inhibit the two-dimensional migration of BEL-7402 cells in a dose-dependent manner[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Schwann cells
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Concentration:5, 100, 200 μg/mL
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Incubation Time:8 h
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Result:Increased the expression of the anti-apoptotic protein Bcl-2 and decreased the expression of the pro-apoptotic proteins Bax, cytochrome c, and caspase-3.
Reduced cell apoptosis rates by 45.9%, 23.2%, and 9.3% at concentrations of 5 μg/mL, 100 μg/mL, and 200 μg/mL, respectively.
Carboxymethyl chitosan (20-120 mg/kg; i.v.; every other day; for seven times) can significantly inhibit the growth of Lewis tumor tissue, increase the spleen index of tumor-bearing mice, and make the liver and lung cells arrange more orderly, indicating its effectiveness in repressing Lewis tumor growth and metastasis[6].
Carboxymethyl chitosan (1350 mg/kg; i.p.) has no significant effects on the coagulation, anticoagulation, fibrinolysis, or hemorheology parameters of rats[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (female, 18-22 g, 6-8 weeks old); Mouse hepatocarcinoma H22-bearing tumor model[4]
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Dosage:75 mg/kg, 150 mg/kg, 300 mg/kg (dissolved in normal saline)
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Administration:Intraperitoneal injection, administered on days 1, 3, 5, 7, 9, 11, 13
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Result:Inhibited the growth of H22 tumor tissue.
Showed inhibition rates of 32.63%, 51.43% and 29.89% at doses of 75 mg/kg, 150 mg/kg and 300 mg/kg, respectively.
Decreased CD34, VEGF and increased TIMP-1.
Increased the thymus index and spleen index of the mice, and enhanced serum IFN-γ and TNF-α levels.
Chemical Information
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CAS. Nr. 83512-85-0
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Appearance Solid
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Color White to light yellow
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SMILES
[Carboxymethyl chitosan]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
H2O : 10 mg/mL (Need ultrasonic)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Chen XG, et al. The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts. Biomaterials. 2002 Dec;23(23):4609-14. [Content Brief]
[2]. Kruczkowska W, et al. Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels. Molecules. 2024 Sep 13;29(18):4360. [Content Brief]
[3]. He B, et al. Carboxymethylated chitosan protects Schwann cells against hydrogen peroxide-induced apoptosis by inhibiting oxidative stress and mitochondria dependent pathway. Eur J Pharmacol. 2018 Apr 15;825:48-56. [Content Brief]
[4]. Jiang Z, et al. Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo. Carbohydr Polym. 2015 Sep 20;129:1-8. [Content Brief]
[5]. Chen Q, et al. Carboxymethyl-chitosan protects rabbit chondrocytes from interleukin-1beta-induced apoptosis. Eur J Pharmacol. 2006 Jul 10;541(1-2):1-8. [Content Brief]
[6]. Jiang Z, et al. Evaluation on biological compatibility of carboxymethyl chitosan as biomaterials for antitumor drug delivery. J Biomater Appl. 2017 Feb;31(7):985-994. [Content Brief]
[7]. Jiang Z, et al. Preparation and anti-tumor metastasis of carboxymethyl chitosan. Carbohydr Polym. 2015 Jul 10;125:53-60. [Content Brief]
[8]. Yang Z, et al. Acute toxicity of high dosage carboxymethyl chitosan and its effect on the blood parameters in rats. J Mater Sci Mater Med. 2012 Feb;23(2):457-62. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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