Carbonic anhydrase-IN-35
Carbonic anhydrase-IN-35 is a selective carbonic anhydrase (CA) inhibitor. Carbonic anhydrase-IN-35 potently inhibits tumor-associated hCA IX (Ki = 0.6 nM) and hCA XII (Ki = 2.2 nM). Carbonic anhydrase-IN-35 induces apoptosis in MCF-7 cells by elevating Bax, reducing Bcl-2, and downregulating CDK4/6. Carbonic anhydrase-IN-35 exhibits potent cytotoxicity against MCF-7 (IC50 = 0.3975 μM normoxic/0.6575 μM hypoxic), MCF-7-ADR (IC50> = 0.3975 μM normoxic/4.488 μM hypoxic), MDA-MB-231, and 4T1 breast cancer cells. Carbonic anhydrase-IN-35 can be used for the study of breast cancer.
For research use only. We do not sell to patients.
- Formula: C17H16N6O4S
- Molecular Weight:400.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA IX 0.6 nM (Ki) |
hCA XII 2.2 nM (Ki) |
hCA I 6183 nM (Ki) |
hCA II 12.7 nM (Ki) |
Carbonic anhydrase-IN-35 (Compound 10a) exhibits potent inhibitory activity against tumor-associated hCA IX (Ki = 0.6 nM), hCA XII (Ki = 2.2 nM), hCA I (Ki = 6183 nM) and hCA II (Ki = 12.7 nM)[1].
Carbonic anhydrase-IN-35 shows potent cytotoxicity against MCF-7 cells under normoxic conditions (IC50 = 0.3975 μM) and hypoxic conditions(IC50 = 0.6575 μM)[1].
Carbonic anhydrase-IN-35 shows potent cytotoxicity against MCF-7-ADR breast cancer cells under normoxic conditions (IC50 = 0.3975 μM) and hypoxic conditions(IC50 = 4.488 μM)[1].
Carbonic anhydrase-IN-35 shows potent anti-proliferative activity against MDA-MB-231 triple-negative breast cancer cells with an IC50 of 1.9 μM and against 4T1 triple-negative breast cancer cells with an IC50 of 2.38 μM[1].
Carbonic anhydrase-IN-35 (24 h) increases the expression of pro-apoptotic Bax, downregulates anti-apoptotic Bcl-2 and CDK4/6 in MCF-7 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 400.41
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Formula C17H16N6O4S
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SMILES
O=S(C1=CC=C(N2N=NC(C(N/N=C/C3=CC=C(O)C=C3)=O)=C2C)C=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carbonic anhydrase-IN-35 Related Classifications
HY-175638 Related Classifications
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