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H2

" in MedChemExpress (MCE) Product Catalog:

638

Inhibitors & Agonists

39

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30

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71

Peptides

22

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73

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Products

61

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38

Isotope-Labeled Compounds

96

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5

Click Chemistry

27

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2

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0940
    H2DCFDA
    Maximum Cited Publications
    747 Publications Verification

    DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate

    		 Fluorescent Dye Reactive Oxygen Species (ROS) Others
    H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) .
    H2DCFDA
  • HY-B0377
    Famotidine
    5+ Cited Publications

    MK-208

    		 Histamine Receptor Cardiovascular Disease Metabolic Disease Endocrinology Cancer
    Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
    Famotidine
  • HY-P990195
    Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8)

    		MHC Others
    Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) reacts with the mouse H-2 MHC class I alloantigen (all haplotypes). Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) can be used for the flow cytometry and immunofluorescence experiments .
    Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8)
  • HY-P1587
    IRBP (1-20), human

    		MHC Inflammation/Immunology
    IRBP (1-20), human contains a major epitope for the H-2 b haplotype. IRBP (1-20), human induces experimental autoimmune uveoretinitis (EAU) in H-2 b mice [2].
    IRBP (1-20), human
  • HY-W013724
    Inosine-5'-diphosphate disodium

    IDP disodium; Inosine-5'-diphosphoric acid disodium

    		 c-Myc Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    Inosine-5'-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research [2] .
    Inosine-5'-diphosphate disodium
  • HY-107616
    H2L5186303
    3 Publications Verification

    		 LPL Receptor Apoptosis Inflammation/Immunology
    H2L5186303 is a potent and selective LPA2 receptor antagonist with an IC50 of 9 nM. H2L5186303 promotes Apoptosis. H2L5186303 inhibits cell proliferation and motility. H2L5186303 has anti-inflammatory effects [2] .
    H2L5186303
  • HY-136500
    Prostaglandin H2

    PGH2

    		 Endogenous Metabolite Amyloid-β Neurological Disease Inflammation/Immunology
    Prostaglandin H2 (PGH2) is an endothelium-derived contracting factor. Prostaglandin H2 can cause vasoconstriction. Prostaglandin H2 is the common precursor of all PGs and is produced by several cells that express cyclooxygen-ases. Prostaglandin H2 can activate PGD2 receptors CRTH2 and DP via interacting directly with the receptors and/or by giving rise to PGD2 after catalytic conversion by plasma proteins. Prostaglandin H2 can induce eosinophils migration and inhibit platelet aggregation. Prostaglandin H2 can accelerate the formation of dimers and higher oligomers of amyloid β1-42. Prostaglandin H2 can be used for the researches of inflammation and neurological disease, such as Alzheimer disease [2] .
    Prostaglandin H2
  • HY-N6911
    Licorice-saponin H2

    (18β,20α)-Glycyrrhizic acid

    		 Others Metabolic Disease
    Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance .
    Licorice-saponin H2
  • HY-B1478
    Dimaprit dihydrochloride

    		Histamine Receptor NO Synthase Endocrinology
    Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion [2].
    Dimaprit dihydrochloride
  • HY-W006524
    H2N-PEG2-CH2COOH

    		PROTAC Linkers Cancer
    H2N-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
    H2N-PEG2-CH2COOH
  • HY-15539
    Niperotidine

    		Histamine Receptor Metabolic Disease Endocrinology
    Niperotidine is a histamine H2-receptor antagonist.
    Niperotidine
  • HY-149101
    Inosine-5'-diphosphate

    IDP; Inosine-5'-diphosphoric acid

    		 c-Myc Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research [2] .
    Inosine-5'-diphosphate
  • HY-E70098
    RNase H2

    		Others Cancer
    RNase H2 is the predominant source of RNase H activity in mammalian and human cells. RNase H2 protects genome integrity. RNase H2 has been associated with ribonucleotide removal from genomic DNA in yeast and mouse, where it is required for embryonic development [2].
    RNase H2
  • HY-135927
    H2N-PEG2-CH2COOtBu

    		PROTAC Linkers Cancer
    H2N-PEG2-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    H2N-PEG2-CH2COOtBu
  • HY-15540
    Metiamide

    SK&F 92058

    		 Histamine Receptor Endocrinology
    Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.
    Metiamide
  • HY-DY1002
    H2DCFDA (solution)

    		Reactive Oxygen Species (ROS) Fluorescent Dye Others
    H2DCFDA (DCFH-DA) (solution) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) .
    Solvent and concentration: DMSO: 10 mM.
    The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
    H2DCFDA (solution)
  • HY-15706
    H2L 5765834
    1 Publications Verification

    		 LPL Receptor Cardiovascular Disease
    H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively .
    H2L 5765834
  • HY-N10225
    Thielavin A

    		Prostaglandin Receptor Cardiovascular Disease Endocrinology
    Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration .
    Thielavin A
  • HY-N7582
    Cimicifugoside H-2

    		Others Others
    Cimicifugoside H-2 is a cyclolanostanol xyloside. Cimicifugoside H-2 can be isolated from Cimicifuga Rhizome .
    Cimicifugoside H-2
  • HY-W008379
    H-2-Nal-OH

    		Amino Acid Derivatives Others
    H-2-Nal-OH is an alanine derivative .
    H-2-Nal-OH
  • HY-116174
    Omaciclovir
    1 Publications Verification

    H2G

    		 HSV Infection
    Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity .
    Omaciclovir
  • HY-130806
    Dihydrodeoxyuridine

    H2dUrd

    		 Nucleoside Antimetabolite/Analog Cancer
    Dihydrodeoxyuridine (H2dUrd) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    Dihydrodeoxyuridine
  • HY-W127820
    H2TMpyP-2 chloride

    Tetrakis(2-N-methylpyridyl)porphine chloride

    		 Biochemical Assay Reagents Fluorescent Dye Others
    H2TMpyP-2 (tetrakis(2-N-methylpyridyl)porphine) chloride is an active photosensitizer with strong absorption properties in the visible to near-infrared region and excellent singlet oxygen quantum yield. Captisol-TMPyP complexes can be used in supramolecular nanosynthesis to increase singlet oxygen production, improve photostability and better photosensitization, and support photodynamic therapy activity. The Captisol:TMPyP complex also exhibited antibacterial activity against Escherichia coli and was cytotoxic against lung cancer A549 cells .
    H2TMpyP-2 chloride
  • HY-101167
    Aminopotentidine

    		Histamine Receptor Others
    Aminopotentidine is a histamine H2 receptor antagonist with KB values of 220 nM and 280 nM for human and guinea pig H2 receptors, respectively. It can also serve as a precursor for the synthesis of [125I] iodo derivatives .
    Aminopotentidine
  • HY-15538
    Ebrotidine

    FI3542

    		 Histamine Receptor Inflammation/Immunology Endocrinology
    Ebrotidine(FI 3542) is a competitive H2-receptor antagonist (Ki= 127.5 nM) with a potent antisecretory activity and evidenced gastroprotection.
    Ebrotidine
  • HY-23199
    H2-003

    		Acyltransferase Metabolic Disease
    H2-003 is a diacylglycerol acyltransferase DGAT2 inhibitor with an IC50 value of 7.4 μM against human targets. H2-003 reduces triacylglycerol biosynthesis and inhibits lipid droplet formation. H2-003 can be used in studies related to hepatic steatosis and insulin resistance .
    H2-003
  • HY-130347
    H2S Donor 5a

    		Endogenous Metabolite Others
    H2S Donor 5a is a cysteine-activated H2S donor. H2S plays important roles in biological systems. H2S Donor 5a is a useful tool in H2S research .
    H2S Donor 5a
  • HY-169331
    H2S scavenger 1 triflate

    		Bacterial Infection
    H2S scavenger 1 triflate is a selective H2S scavenger and antibacterial adjuvant. H2S scavenger 1 triflate consumes hydrogen sulfide produced by H2S-producing bacteria via chemical scavenging, and does not act on H2S synthases. H2S scavenger 1 triflate enhances the clearance of H2S-producing bacteria mediated by macrophages and polymorphonuclear neutrophils. H2S scavenger 1 triflate inhibits the biofilm formation of H2S-producing bacteria and eliminates pre-formed biofilms. H2S scavenger 1 triflate can be used for the research of Pseudomonas aeruginosa-infected pneumonia and Pseudomonas aeruginosa-infected skin wounds .
    H2S scavenger 1 triflate
  • HY-D2476
    H2S Fluorescent probe 1

    		Fluorescent Dye Others
    H2S Fluorescent probe 1 (Compound 2) is a fluorescent probe that detects hydrogen sulfide (H2S) with almost no cytotoxicity. Upon the addition of increasing amounts of HS - to DMSO solution of H2S Fluorescent probe 1, a new absorption peak appears gradually at 485 nm. H2S Fluorescent probe 1, the fluorescence intensity notes at 434 nm increasing rapidly by titration of HS - .
    H2S Fluorescent probe 1
  • HY-101052
    HTMT dimaleate

    		Histamine Receptor Inflammation/Immunology
    HTMT (dimaleate) is a potent histamine H1 and H2 receptor agonist. HTMT (dimaleate) is 4 x 10 4 times more active than histamine in H2-mediated effects in natural suppressor cells .
    HTMT dimaleate
  • HY-N14083
    Monamycin H2

    		Antibiotic Bacterial Infection
    Monamycin H2 is an ester peptide antibiotic. Monamycin H2 has activity against Gram-positive bacteria .
    Monamycin H2
  • HY-133327
    Amino-PEG12-amine

    H2N-PEG12-CH2CH2NH2

    		 PROTAC Linkers Cancer
    Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Amino-PEG12-amine
  • HY-133328
    Amino-PEG13-amine

    H2N-PEG13-CH2CH2NH2

    		 PROTAC Linkers Cancer
    Amino-PEG13-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Amino-PEG13-amine
  • HY-P5674
    Bombinin H2

    		Bacterial Infection
    Bombinin H2 is an antimicrobial peptide derived from the skin of moth Bombina variegata .
    Bombinin H2
  • HY-P5618
    Maximin H2

    		Bacterial Infection
    Maximin H2 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H2 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 20, 2, 4, 2 μg/ml, respectively .
    Maximin H2
  • HY-N6911B
    Licorice-saponin H2 ammonium

    (18β,20α)-Glycyrrhizic acid ammonium

    		 Others Metabolic Disease
    Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) ammonium is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 ammonium accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance .
    Licorice-saponin H2 ammonium
  • HY-135927A
    H2N-PEG2-CH2COOtBu hydrochloride

    		PROTAC Linkers Cancer
    H2N-PEG2-CH2COOtBu (hydrochloride) is a PROTAC linker that can be used in the synthesis of PROTACs.
    H2N-PEG2-CH2COOtBu hydrochloride
  • HY-19048
    CP-66948

    		Histamine Receptor Endocrinology
    CP-66948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties.
    CP-66948
  • HY-N13170
    Glycoside H2

    		Others Neurological Disease
    Glycoside H2 is a potentiator of NGF-mediated nerve fiber outgrowth .
    Glycoside H2
  • HY-121455
    Lamtidine

    		Histamine Receptor Metabolic Disease
    Lamtidine is a histamine H2 receptor antagonist. Lamtidine has analogues and derivatives that exhibit stronger activity .
    Lamtidine
  • HY-19007
    Mifentidine

    DA 4577

    		 Histamine Receptor Endocrinology
    Mifentidine (DA 4577) is a potent and selective H2 Receptor antagonist. Mifentidine has an anti-secretion effect and can antagonize the acid-promoting activity of histamine with EC50 3.28 μM .
    Mifentidine
  • HY-153911
    H2-Gamendazole

    		HSP CFTR Endocrinology
    H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research .
    H2-Gamendazole
  • HY-160979
    Bisfentidine

    DA-5047

    		 Histamine Receptor Others Endocrinology
    Bisfentidine is an H2 receptor antagonist, Bisfentidine can block the H2 receptor on the cells of the stomach wall, and reduce the secretion of stomach acid. Bisfentidine binds to cytochrome P-450 in liver microsomes and affects drug metabolism. Bisfentidine can be used in the study of metabolic processes of drugs, lipid peroxidation processes and peptic ulcers diseases .
    Bisfentidine
  • HY-P3070
    H2-D b restricted epitopes VSV Nucleoprotein (52-59)

    		MHC Infection Others
    H2-D b restricted epitopes VSV Nucleoprotein (52-59) is a 9-mer peptide derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). H2-D b restricted epitopes VSV Nucleoprotein (52-59) binds to MHC class I molecules and presents itself to CD8+ T cells, thereby activating cytotoxic T lymphocytes (CTLs), which can recognize and kill cells expressing the corresponding antigen. H2-D b restricted epitopes VSV Nucleoprotein (52-59) can be used in the development of CTL vaccines against Ebola virus .
    H2-D b restricted epitopes VSV Nucleoprotein (52-59)
  • HY-W039696
    H2N-PEG2-CH2COOH hydrochloride

    		PROTAC Linkers Cancer
    H2N-PEG2-CH2COOH (hydrochloride) is a PROTAC linker that can be used in the synthesis of PROTACs.
    H2N-PEG2-CH2COOH hydrochloride
  • HY-W1048545H
    H2N-PEG1000-SH hydrochloride

    Amine-PEG1000-Thiol hydrochloride

    		 Biochemical Assay Reagents Others
    H2N-PEG1000-SH (Amine-PEG1000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG1000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
    H2N-PEG1000-SH hydrochloride
  • HY-W854275
    (H2IPr)(Cl)2Ru=CH(o-iPrOC6H4)

    		Biochemical Assay Reagents Endogenous Metabolite
    (H2IPr)(Cl)2Ru=CH(o-iPrOC6H4) is a highly efficient catalyst that can effectively promote the metathesis reaction of olefins. The compound exhibits excellent selectivity in the field of transition metal catalysts, is suitable for the synthesis of biologically active compounds, and shows potential application value in compound development.
    (H2IPr)(Cl)2Ru=CH(o-iPrOC6H4)
  • HY-100191
    BMY-25271

    		Histamine Receptor Inflammation/Immunology Endocrinology
    BMY-25271 is a histamine H2 receptor antagonist.
    BMY-25271
  • HY-167662
    Sopromidine

    		Histamine Receptor Drug Isomer Others
    Sopromidine is a potent and stereoselective isomer of the achiral H2-agonist Impromidine (HY-116777) .
    Sopromidine
  • HY-106078
    Oxmetidine

    SKF 92994

    		 Histamine Receptor Inflammation/Immunology
    Oxmetidine (SKF 92994) is an orally active H2-receptor antagonist, and is an anti-ulcer agent .
    Oxmetidine

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