Cat. No.: HY-15035

S-Diclofenac

(Synonyms: ACS 15; ATB-337)

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Based on 1 Customer Validation

S-Diclofenac (ACS 15) is a hybrid molecule of an H₂S donor and the NSAID diclofenac. S-Diclofenac activates the p53 signaling pathway, and inhibits the activation of JNK. S-Diclofenac exhibits antioxidant and anti-inflammatory activities.

For research use only. We do not sell to patients.

Purity: 99.20%
CAS No.: 912758-00-0
Formula: C₂₃H₁₅Cl₂NO₂S₃
Molecular Weight:504.47

Storage:

4°C, stored under nitrogen, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

S-Diclofenac Chemical Structure

CAS No.: 912758-00-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All JNK Isoforms :

In Vitro

S-Diclofenac (0-100 μM, 48 h) induces the expression of p53 protein, thereby activating downstream proteins such as p21, p53AIP1 and Bax. S-Diclofenac arrests the cell cycle at sub-G1 phase, and induces apoptosis in rat aortic vascular smooth muscle cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:

rat aortic vascular smooth muscle cells
Concentration:

50 μM
Incubation Time:

48 h
Result:

Upregulated the expressions of p53, p21, p53AIP1 and Bax protein.

Apoptosis Analysis^[4]

Cell Line:

rat aortic vascular smooth muscle cells
Concentration:

0-100 μM
Incubation Time:

48 h
Result:

Induced apoptosis.

In Vivo

S-Diclofenac (6-24 mg/kg, ip, single dose) releases hydrogen sulfide (H₂S) and inhibits cyclooxygenase-mediated inflammatory responses, ameliorates Carrageenan (HY-125474)-induced hindpaw edema in rats models^[2].
S-Diclofenac (12.5-25 mg/kg, ip, one daily for 14 days) reverses the remodeling of cardiac gap junctions, alleviates oxidative stress and inflammatory response, thereby reducing Doxorubicin (HY-15142)-induced myocardial injury and cardiac dysfunction in mouse models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Carrageenan-induced rats hindpaw edema models^[2]
Dosage:

6-24 mg/kg
Administration:

ip, single dose
Result:

Decreased the myeloperoxidase activity, inhibited hind paw edema.

Animal Model:

Doxorubicin-induced mouse cardiomyopathy models^[3]
Dosage:

12.5-25 mg/kg
Administration:

ip, one daily for 14 days
Result:

Inhibited the downregulation of cardiac gap junction proteins Cx43 and Cx45.
Increased the activity of SOD, MPO and GSH-Px in the heart and reduced the level of MDA.
Improved the survival rate of mice.

Chemical Information

CAS No. 912758-00-0
Appearance Solid
Molecular Weight 504.47
Formula C₂₃H₁₅Cl₂NO₂S₃
Color Reddish brown to red
SMILES

O=C(CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1)OC3=CC=C(C(SS4)=CC4=S)C=C3
Synonyms

ACS 15; ATB-337
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (198.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9823 mL

9.9114 mL

19.8228 mL

5 mM

0.3965 mL

1.9823 mL

3.9646 mL

10 mM

0.1982 mL

0.9911 mL

1.9823 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wallace JL, et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology. 2007 Jan;132(1):261-71. [Content Brief]

[2]. Sidhapuriwala J, et al., Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. Eur J Pharmacol. 2007 Aug 13;569(1-2):149-54. [Content Brief]

[3]. Zhang H, et al., S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling. PLoS One. 2011;6(10):e26441 [Content Brief]

[4]. Baskar R, et al., Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation. Eur J Pharmacol. 2008 Oct 10;594(1-3):1-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9823 mL	9.9114 mL	19.8228 mL	49.5570 mL
	5 mM	0.3965 mL	1.9823 mL	3.9646 mL	9.9114 mL
	10 mM	0.1982 mL	0.9911 mL	1.9823 mL	4.9557 mL
	15 mM	0.1322 mL	0.6608 mL	1.3215 mL	3.3038 mL
	20 mM	0.0991 mL	0.4956 mL	0.9911 mL	2.4778 mL
	25 mM	0.0793 mL	0.3965 mL	0.7929 mL	1.9823 mL
	30 mM	0.0661 mL	0.3304 mL	0.6608 mL	1.6519 mL
	40 mM	0.0496 mL	0.2478 mL	0.4956 mL	1.2389 mL
	50 mM	0.0396 mL	0.1982 mL	0.3965 mL	0.9911 mL
	60 mM	0.0330 mL	0.1652 mL	0.3304 mL	0.8259 mL
	80 mM	0.0248 mL	0.1239 mL	0.2478 mL	0.6195 mL
	100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.4956 mL

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S-Diclofenac

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Mass Spectrometry Human Metabolite Library

All JNK Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

S-Diclofenac Related Classifications

HY-15035 Related Classifications