912758-00-0
912758-00-0
Chemical Structure
S-Diclofenac
Synonym(s): ACS 15; ATB-337
- CAS No.: 912758-00-0
- Formula:C23H15Cl2NO2S3
- Molecular Weight:504.47
IUPAC Name: 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate
InChIKey: BRDUXOHVEZVAHI-UHFFFAOYSA-N
SMILES: O=C(CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1)OC3=CC=C(C(SS4)=CC4=S)C=C3
Biological Activity: S-Diclofenac (ACS 15) is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac activates the p53 signaling pathway, and inhibits the activation of JNK. S-Diclofenac exhibits antioxidant and anti-inflammatory activities[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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S-Diclofenac | 99.20% | S-Diclofenac (ACS 15) is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac activates the p53 signaling pathway, and inhibits the activation of JNK. S-Diclofenac exhibits antioxidant and anti-inflammatory activities. | ||||||||||||||||||||
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S-Diclofenac (Standard) | ≥98% | S-Diclofenac (Standard) is the analytical standard of S-Diclofenac. This product is intended for research and analytical applications. S-Diclofenac (ACS 15) is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac activates the p53 signaling pathway, and inhibits the activation of JNK. S-Diclofenac exhibits antioxidant and anti-inflammatory activities. | ||||||||||||||||||||
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References
- [1]. Wallace JL, et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology. 2007 Jan;132(1):261-71. [Content Brief]
- [2]. Sidhapuriwala J, et al., Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. Eur J Pharmacol. 2007 Aug 13;569(1-2):149-54. [Content Brief]
- [3]. Zhang H, et al., S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling. PLoS One. 2011;6(10):e26441 [Content Brief]
- [4]. Baskar R, et al., Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation. Eur J Pharmacol. 2008 Oct 10;594(1-3):1-8. [Content Brief]
Keywords
