2. Immunology/Inflammation
  3. MHC
  4. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159)

Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) 

Cat. No.: HY-P990194
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Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) reacts with the mouse H-2Kd MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) can be used for immunology research, such as cardiac graft.

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Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159)

Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) Estructura química

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Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) Related Antibodies

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Descripciòn

Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) reacts with the mouse H-2Kd MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) can be used for immunology research, such as cardiac graft[1].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) Related Antibodies
In Vivo

Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) (750 μg, i.v., at day 3 posttransplant) induces histological features antibody-mediated rejection in in Murine Cardiac Allografts mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (H-2d) hearts were heterotopically transplanted into B6.RAG1 KO (H-2b) mice[1]
Dosage: 750 μg
Administration: Intravenously injection, at day 3 posttransplant
Result: Increased in microvascular changes.
Showed a significant accumulation of intravascular Mac2-positive macrophages in the myocardial capillaries.
Exhibited a significant increase in protein phosphorylation of grafts.
Application

Purification of MHC peptide complexes; in vivo administration; Flow cytometry
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

150 kDa

SMILES

[Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159)MHCMajor Histocompatibility ComplexMHC Class IH-2Kd Cardiac graftBALB/cInhibitorinhibitorinhibit

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Nombre del producto:
Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159)
Cat. No.:
HY-P990194
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