2. Cell Cycle/DNA Damage Others
  3. DNA/RNA Synthesis Fluorescent Dye
  4. ICR-191 dihydrochloride

ICR-191 dihydrochloride enhances Cisplatin (HY-17394)- DNA binding and sensitizes cells to cisplatin. ICR-191 dihydrochloride induces a significant increase in the expression of phosphorylated H2AX (γH2AX), particularly in DNA-replicating cells. ICR-191 dihydrochloride can be used for the study of leukemia.

For research use only. We do not sell to patients.

ICR-191 dihydrochloride

ICR-191 dihydrochloride Chemical Structure

CAS No. : 17070-45-0

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ICR-191 dihydrochloride Related Antibodies

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Description

ICR-191 dihydrochloride enhances Cisplatin (HY-17394)- DNA binding and sensitizes cells to cisplatin. ICR-191 dihydrochloride induces a significant increase in the expression of phosphorylated H2AX (γH2AX), particularly in DNA-replicating cells. ICR-191 dihydrochloride can be used for the study of leukemia[1][2].

In Vitro

ICR-191 dihydrochloride (16 h)-induced mutations (such as G insertion) create new GG sites in CHO-ICR cells, leading to an increase in the number of cisplatin binding sites. The IC50 of cisplatin in CHO-ICR cells (IC50 = 15.96 μM) is reduced to half that of CHO wild-type (WT) cells (IC50 = 25.42 μM)[1].
ICR-191 dihydrochloride (8-12 μM) fluorescence is quenched with increasing CHL concentration[2].
ICR-191 dihydrochloride (8-10.1 μM) binds to DNA via intercalation, but its affinity is relatively low[2].
ICR-191 dihydrochloride (1.2 μM, 1 h) can induce histone H2AX phosphorylation (γH2AX) in HL-60 cells, especially in S-phase cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ICR-191 dihydrochloride Related Antibodies
Molecular Weight

451.22

Formula

C19H23Cl4N3O
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

ClC1=CC2=NC(C=CC(OC)=C3)=C3C(NCCCNCCCl)=C2C=C1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Purity & Documentation
References
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ICR-191 dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICR-19117070-45-0ICR191ICR 191DNA/RNA SynthesisFluorescent DyeChlorophyllinDNA damageHistone H2AX phosphorylationMutagen interceptorIntercalationCompetitive interactionsInhibitorinhibitorinhibit

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ICR-191 dihydrochloride
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HY-W414334
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