ICR-191 dihydrochloride
Based on 1 Customer Validation
ICR-191 dihydrochloride enhances Cisplatin (HY-17394)- DNA binding and sensitizes cells to cisplatin. ICR-191 dihydrochloride induces a significant increase in the expression of phosphorylated H2AX (γH2AX), particularly in DNA-replicating cells. ICR-191 dihydrochloride can be used for the study of leukemia.
For research use only. We do not sell to patients.
- CAS No.: 17070-45-0
- Formula: C19H23Cl4N3O
- Molecular Weight:451.22
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
ICR-191 dihydrochloride (16 h)-induced mutations (such as G insertion) create new GG sites in CHO-ICR cells, leading to an increase in the number of cisplatin binding sites. The IC50 of cisplatin in CHO-ICR cells (IC50 = 15.96 μM) is reduced to half that of CHO wild-type (WT) cells (IC50 = 25.42 μM)[1].
ICR-191 dihydrochloride (8-12 μM) fluorescence is quenched with increasing CHL concentration[2].
ICR-191 dihydrochloride (8-10.1 μM) binds to DNA via intercalation, but its affinity is relatively low[2].
ICR-191 dihydrochloride (1.2 μM, 1 h) can induce histone H2AX phosphorylation (γH2AX) in HL-60 cells, especially in S-phase cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 17070-45-0
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Appearance Solid
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Molecular Weight 451.22
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Formula C19H23Cl4N3O
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Color Light yellow to green yellow
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SMILES
ClC1=CC2=NC(C=CC(OC)=C3)=C3C(NCCCNCCCl)=C2C=C1.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
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Data Sheet (271 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
[1]. Shao C, et al. Pt-seq unveils the genomic binding pattern of platinum-based drugs. Sci Adv. 2025 Oct 31;11(44):eadx6809. [Content Brief]
[2]. Pietrzak M, et al. Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin. Biophys Chem. 2008 Jun;135(1-3):69-75. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ICR-191 dihydrochloride Related Classifications
HY-W414334 Related Classifications
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