ICR-191 dihydrochloride

Name: ICR-191 dihydrochloride
Brand: MedChemExpress
SKU: HY-W414334
Rating: 4.5 (1 reviews)

Cat. No.: HY-W414334: Ficha de datos
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ICR-191 dihydrochloride enhances Cisplatin (HY-17394)- DNA binding and sensitizes cells to cisplatin. ICR-191 dihydrochloride induces a significant increase in the expression of phosphorylated H2AX (γH2AX), particularly in DNA-replicating cells. ICR-191 dihydrochloride can be used for the study of leukemia.

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ICR-191 dihydrochloride Estructura química

No. CAS : 17070-45-0

Tamaño	Stock	Cantidad
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
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500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

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Descripciòn

In Vitro

ICR-191 dihydrochloride (16 h)-induced mutations (such as G insertion) create new GG sites in CHO-ICR cells, leading to an increase in the number of cisplatin binding sites. The IC₅₀ of cisplatin in CHO-ICR cells (IC₅₀ = 15.96 μM) is reduced to half that of CHO wild-type (WT) cells (IC₅₀ = 25.42 μM)^[1].
ICR-191 dihydrochloride (8-12 μM) fluorescence is quenched with increasing CHL concentration^[2].
ICR-191 dihydrochloride (8-10.1 μM) binds to DNA via intercalation, but its affinity is relatively low^[2].
ICR-191 dihydrochloride (1.2 μM, 1 h) can induce histone H2AX phosphorylation (γH2AX) in HL-60 cells, especially in S-phase cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

451.22

Fòrmula

C₁₉H₂₃Cl₄N₃O

No. CAS

17070-45-0

Appearance

Solid

Color

Light yellow to green yellow

SMILES

ClC1=CC2=NC(C=CC(OC)=C3)=C3C(NCCCNCCCl)=C2C=C1.Cl.Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Pureza y Documentación

Purity: ≥95.0%

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Ficha de datos (271 KB) SDS (644 KB)

COA (251 KB) HNMR (133 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Shao C, et al. Pt-seq unveils the genomic binding pattern of platinum-based drugs. Sci Adv. 2025 Oct 31;11(44):eadx6809. [Content Brief]

[2]. Pietrzak M, et al. Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin. Biophys Chem. 2008 Jun;135(1-3):69-75. [Content Brief]