17070-45-0
17070-45-0
Chemical Structure
ICR-191 dihydrochloride
- CAS No.: 17070-45-0
- Formula:C19H23Cl4N3O
- Molecular Weight:451.22
IUPAC Name: 4-amino-2-iodopyridin-3-ol
InChIKey: LMEMIKWTNPWYMI-UHFFFAOYSA-N
SMILES: ClC1=CC2=NC(C=CC(OC)=C3)=C3C(NCCCNCCCl)=C2C=C1.Cl.Cl
Biological Activity: ICR-191 dihydrochloride enhances Cisplatin (HY-17394)- DNA binding and sensitizes cells to cisplatin. ICR-191 dihydrochloride induces a significant increase in the expression of phosphorylated H2AX (γH2AX), particularly in DNA-replicating cells. ICR-191 dihydrochloride can be used for the study of leukemia[1][2].
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ICR-191 dihydrochloride | ICR-191 dihydrochloride enhances Cisplatin (HY-17394)- DNA binding and sensitizes cells to cisplatin. ICR-191 dihydrochloride induces a significant increase in the expression of phosphorylated H2AX (γH2AX), particularly in DNA-replicating cells. ICR-191 dihydrochloride can be used for the study of leukemia. | |||||||||||||||||||||
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References
- [1]. Shao C, et al. Pt-seq unveils the genomic binding pattern of platinum-based drugs. Sci Adv. 2025 Oct 31;11(44):eadx6809. [Content Brief]
- [2]. Pietrzak M, et al. Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin. Biophys Chem. 2008 Jun;135(1-3):69-75. [Content Brief]
Keywords
