RAD51L1 Antibody (YA8524)
(Synonyms: R51H2; RAD51L1; REC2)RAD51L1 Antibody (YA8524) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAD51L1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC
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Reactivity :
Human, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
RAD51L1 Antibody (YA8524) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAD51L1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 42 kDa
Human recombinant protein fragment corresponding to amino acids 119-346 of human RAD51L1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RAD51L1 is involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Expressed in a wide range of tissues -
Isoforms & Post-Translational Modification
O15315 has 5 isomers: O15315-3: 42196 Da (predicted); O15315-1: 38257 Da (predicted); O15315-2: 38304 Da (predicted); O15315-4: 40284 Da (predicted); O15315-5: 25527 Da (predicted).
Phosphorylated on tyrosine residues by BCR-ABL -
Subunit
Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel (PubMed:11744692, PubMed:11751635, PubMed:11751636, PubMed:11842112, PubMed:11842113, PubMed:12427746, PubMed:14704354)
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SwissProt ID
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Synonyms
R51H2; RAD51L1; REC2
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