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Referencia número: HY-173619

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EGFR-IN-160

EGFR-IN-160 (Compound R12) is an EGFR inhibitor (IC₅₀ values are 1.62, 0.49 and 0.98 μM for EGFR^WT, EGFR^T790M and EGFR^{L858R/T790M/C797S}, respectively). EGFR-IN-160 induces G2/M and S phase arrest and apoptosis in NCI-H522 cells, and has anticancer activity. EGFR-IN-160 has antioxidant effects against DPPH (IC₅₀: 12.11 µM) and H2O2 (IC₅₀: 8.89 µM).

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No. CAS: 2172879-84-2
Fòrmula: C₁₅H₁₂N₂O₄
Peso molecular:284.27

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

EGFR-IN-160 Chemical Structure

No. CAS: 2172879-84-2

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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Ver todos los productos específicos de isoformas EGFR :

Chemical Information

No. CAS 2172879-84-2
Peso molecular 284.27
Fòrmula C₁₅H₁₂N₂O₄
SMILES

COC1=CC(C2=CC(C3=CC=CO3)=NC(O)=N2)=CC=C1O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Pal R, et al. Design, Synthesis, and Molecular Profiling of Pyrimidine-Furan Derivatives Targeting EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S in NSCLC: In Vitro and In Silico Evaluation. Chem Biodivers. 2025 Apr 19:e202500549. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EGFR-IN-160

Ver todos los productos específicos de isoformas EGFR

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Referencias

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EGFR-IN-160 Related Classifications

HY-173619 Related Classifications