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Cat. No.: HY-100191

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BMY-25271

BMY-25271 is a histamine H2 receptor antagonist.

For research use only. We do not sell to patients.

CAS No.: 78441-82-4
Formula: C₁₂H₁₉N₅O₂S₂
Molecular Weight:329.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BMY-25271 Chemical Structure

CAS No.: 78441-82-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

BMY-25271 is a histamine H2 receptor antagonist.

IC₅₀ & Target

H₂ Receptor

All Histamine Receptor Isoforms :

In Vivo

BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED₅₀ values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 78441-82-4
Molecular Weight 329.44
Formula C₁₂H₁₉N₅O₂S₂
SMILES

NC1=NS(N=C1NCCSCC2=CC=C(CN(C)C)O2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cavanagh RL, et al. Prevention of aspirin-induced gastric mucosal injury by histamine H2 receptor antagonists: a crossover endoscopic and intragastric pH study in the dog. J Pharmacol Exp Ther. 1987 Dec;243(3):1179-84. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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BMY-25271

All Histamine Receptor Isoforms

Biological Activity

Description

IC50 & Target

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BMY-25271 Related Classifications

HY-100191 Related Classifications

Bioz

Keywords

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