1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

BMY-25271 

Cat. No.: HY-100191
Handling Instructions

BMY-25271 is a histamine H2 receptor antagonist.

For research use only. We do not sell to patients.

BMY-25271 Chemical Structure

BMY-25271 Chemical Structure

CAS No. : 78441-82-4

Size Price Stock
1 mg USD 1127 Get quote
5 mg USD 1803 Get quote
10 mg USD 2885 Get quote

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

BMY-25271 is a histamine H2 receptor antagonist.

IC50 & Target

Histamine H2 receptor[1]

In Vivo

BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED50 values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0355 mL 15.1773 mL 30.3545 mL
5 mM 0.6071 mL 3.0355 mL 6.0709 mL
10 mM 0.3035 mL 1.5177 mL 3.0355 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Five beagle dogs are used in this study. Vehicle or BMY-25271 (0.4 mg/kg) is administered orally 1 h before aspirin (100 mg/kg). Blood samples are collected from the jugular vein just before aspirin administration and 30, 60, 90 and 120 min after aspirin administration. One week later, the dogs are crossed over, and the study is repeated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

329.44

Formula

C₁₂H₁₉N₅O₂S₂

CAS No.

78441-82-4

SMILES

NC1=NS(N=C1NCCSCC2=CC=C(CN(C)C)O2)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
BMY-25271
Cat. No.:
HY-100191
Quantity:

BMY-25271

Cat. No.: HY-100191