2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species (ROS) TNF Receptor
  4. Neuroprotective agent 10

Neuroprotective agent 10 is an orally active, blood-brain barrier permeable neuroprotective agent. Neuroprotective agent 10 scavenges ABTS, DPPH and superoxide anion free radicals. Neuroprotective agent 10 inhibits abnormal electrical discharges. At the cellular level, Neuroprotective agent 10 alleviates H2O2-induced oxidative damage and LPS (HY-D1056)-induced neuroinflammation, and relieves epileptic symptoms and oxidative damage in mice. Neuroprotective agent 10 can be used in the research of epilepsy.

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Neuroprotective agent 10

Neuroprotective agent 10 Chemical Structure

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Neuroprotective agent 10 Related Antibodies

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Description

Neuroprotective agent 10 is an orally active, blood-brain barrier permeable neuroprotective agent. Neuroprotective agent 10 scavenges ABTS, DPPH and superoxide anion free radicals. Neuroprotective agent 10 inhibits abnormal electrical discharges. At the cellular level, Neuroprotective agent 10 alleviates H2O2-induced oxidative damage and LPS (HY-D1056)-induced neuroinflammation, and relieves epileptic symptoms and oxidative damage in mice. Neuroprotective agent 10 can be used in the research of epilepsy[1].

In Vitro

Neuroprotective agent 10 (Compound 11c) potently scavenges ABTS, DPPH and superoxide anion radicals in cell-free assays, with IC50 values of 92.0 μM, 70.9 μM, and an inhibition rate of 48.4% (at a concentration of 2.5 mM)[1].
Neuroprotective agent 10 (10-100 μM; 24 h) exhibits no cytotoxicity against HT22 mouse hippocampal neuronal cells at a concentration of 50.0 μM, but reduces cell viability to 88.8% of that in the control group after 24 h of incubation at a concentration of 100.0 μM[1].
Neuroprotective agent 10 (10-100 μM; 24 h) significantly protects HT22 mouse hippocampal neurons against H2O2-induced damage at a concentration of 50.0 μM, and reduces cell damage by 36.0% in a dose-dependent manner[1].
Neuroprotective agent 10 (2.5-50 μM; 24 h) potently inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) release by up to 92.5% and tumor necrosis factor-α (TNF-α) release by up to 76.2% in a dose-dependent manner in BV-2 mouse microglial cells[1].
Neuroprotective agent 10 (50 μM; 8.5 h) potently inhibits LPS-induced reactive oxygen species (ROS) production in BV-2 mouse microglia at a concentration of 50.0 μM, with an inhibition rate of 91.2%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuroprotective agent 10 Related Antibodies

Oxidative Stress[1]

Cell Line: HT22 mouse hippocampal neuronal cells
Concentration: 10, 50 and 100 μM
Incubation Time: 24 h
Result: Reduced H2O2-induced cell damage by 36.0% in a dose-dependent manner at 50.0 μM.
Showed lower cell viability at 100.0 μM than at 50.0 μM, likely due to combined neuroprotective and cytotoxic effects.

ELISA Assay[1]

Cell Line: LPS-activated BV-2 mouse microglial cells
Concentration: 50 μM
Incubation Time: 8 h preincubation, followed by 30 min LPS co-incubation
Result: Inhibited LPS-induced ROS production by 91.2% at 50.0 μM.
Parmacokinetics
Species Dose Route Cmax (Brain) Tmax (Brain) T1/2 (Brain) Cmax Tmax (Plasma) T1/2 (Plasma) AUC0-t
Mice[1] 50.0 mg/kg i.g. 2.4 μg/g 0.5 h 3.5 h 14.5 μg/mL 0.5 h 3.6 h 39.1 mg/h/L
In Vivo

Compound 11c (50.0 mg/kg; i.g.; single administration) exhibits potent anticonvulsant activity in pentylenetetrazol-induced epileptic model mice[1].
Compound 11c (50.0 mg/kg; i.g.; single administration) exhibits significant anticonvulsant activity in pilocarpine (HY-B0726A)-induced epileptic model mice[1].
Compound 11c (50.0 mg/kg; i.g.; once daily; for 4 consecutive weeks) exhibits potent in vivo antioxidant activity in mice with oxidative stress induced by Sodium Nitrite (HY-N11218), which reduces MDA levels, enhances SOD activity and alleviates neuronal damage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J (adult male, pentylenetetrazole-induced clonic seizures)[1]
Dosage: 50.0 mg/kg
Administration: i.g.; single administration 60 minutes prior to PTZ challenge
Result: Extended the latency to the first clonus by 141.7%.
Reduced the number of seizure episodes by 50.0%.
Animal Model: C57BL/6 J (adult male, pilocarpine-induced tonic-clonic seizures)[1]
Dosage: 50.0 mg/kg
Administration: i.g.; single administration 60 minutes prior to pilocarpine challenge
Result: Extended the latency to status epilepticus by 138.1%.
Animal Model: C57BL/6 J (adult male, sodium nitrite-induced oxidative stress)[1]
Dosage: 50.0 mg/kg
Administration: i.g.; once daily; 4 weeks
Result: Reduced cerebral cortex MDA content.
Increased cerebral cortex SOD activity.
Improved hippocampal neuronal damage observed via immunohistochemical staining.
Molecular Weight

321.41

Formula

C17H27N3O3
SMILES

OC1=C(OC)C=C(CNCCCN2CCCC(C(N)=O)C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Neuroprotective agent 10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuroprotective agent 10Neuroprotective agent10Neuroprotective agent-10Reactive Oxygen Species (ROS)TNF ReceptorTumor Necrosis Factor ReceptorTNFRpilocarpine-induced seizure model micepentylenetetrazole-induced seizure model miceneuroinflammationBV-2 mouse microglial cellsHT22 mouse hippocampal neuronal cellsoxidative damageDPPH radicalsABTS radicalssuperoxide anion radicalsepilepsyInhibitorinhibitorinhibit

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