NH2-Gly-PAB-Exatecan-D-glucuronic acid formic
Based on 1 Customer Validation
NH2-Gly-PAB-Exatecan-D-glucuronic acid formic (Compound 8) is an intermediate that reacts with NHS-group-containing molecules to generate the ADC drug-linker conjugate Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179).
For research use only. We do not sell to patients.
- Purity : 98.87%
- Formula: C41H42FN5O16
- Molecular Weight:879.79
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Description
In Vitro
Mal-Gly-PAB-Exatecan-D-glucuronic acid is used for the synthesis of antibody-drug conjugates (ADCs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 879.79
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Formula C41H42FN5O16
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Color White to light yellow
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SMILES
NCC(NC(C=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=C(C=C1)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O.OC=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (56.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1366 mL | 5.6832 mL | 11.3663 mL | 28.4159 mL |
| 5 mM | 0.2273 mL | 1.1366 mL | 2.2733 mL | 5.6832 mL | |
| 10 mM | 0.1137 mL | 0.5683 mL | 1.1366 mL | 2.8416 mL | |
| 15 mM | 0.0758 mL | 0.3789 mL | 0.7578 mL | 1.8944 mL | |
| 20 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4208 mL | |
| 25 mM | 0.0455 mL | 0.2273 mL | 0.4547 mL | 1.1366 mL | |
| 30 mM | 0.0379 mL | 0.1894 mL | 0.3789 mL | 0.9472 mL | |
| 40 mM | 0.0284 mL | 0.1421 mL | 0.2842 mL | 0.7104 mL | |
| 50 mM | 0.0227 mL | 0.1137 mL | 0.2273 mL | 0.5683 mL |
NH2-Gly-PAB-Exatecan-D-glucuronic acid formic Related Classifications
HY-160885A Related Classifications
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