Catalase, Aspergillus niger
Based on 6 publication(s) in Google Scholar
Catalase, Aspergillus niger is a key enzyme in the metabolism of H2O2 and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors. Free oxygen radical scavenger.
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- No. CAS: 9001-05-2
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Publications Citing Use of MedChemExpress (MCE) Catalase, Aspergillus niger
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Actividad biológica
Descripciòn
In Vitro
Product Information
Produced through fermentation by Aspergillus niger, it remains effective within a pH range of 4.0 to 10.0 and a temperature range of 35°C to 40°C.
Instructions
It can be dissolved using water or as specified in relevant references.
Note: When decomposing hydrogen peroxide, if the concentration of hydrogen peroxide is excessively high (≥1000 mg/L), the reaction rate of the enzyme will decrease.
Catalase, the enzyme that metabolizes H2O2 but also reacts with a multitude of other substrates. The active site of catalase contains an iron atom. Human catalase contains four identical subunits, each subunit containing four distinct domains and one prosthetic heme group. The four domains include: (1) a N-terminal arm which contains a distal histidine, an essential amino acid for the catalase reaction; (2) a β-barrel domain that contains eight β-barrels arranged in an antiparallel fashion with six α-helical insertions, conferring the hydrophobic core of the protein necessary for the tri-dimensional structure of the enzyme; (3) a connection domain which contains the tyrosine residue that binds the heme group; and finally (4) an α-helical domains, which is important for NADPH binding[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
EC Number
1.11.1.6
Enzyme Activity
≥200000 U/g
Unit Definition
One unit is defined as the amount of enzyme that can hydrolyze 1.0 μmole H2O2 per min at pH 7.0 and 25°C
Chemical Information
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No. CAS 9001-05-2
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Appearance Solid
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Color Off-white to light yellow
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SMILES
[Catalase, Aspergillus niger]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Nat Chem Biol
2025 Jun 2. PMID: 40456963 -
Cancer Lett
Vesicular QSOX1-MMP2 from inflammatory cancer-associated fibroblasts degrades the extracellular matrix to drive colorectal cancer pulmonary dissemination. [Abstract]2026 Sep 28:656:218645. PMID: 42217558 -
Catalase, Aspergillus niger purchased from MedChemExpress. Usage Cited in: BioChip J. 2025 Aug 1.
ROS scavenger Catalase, Aspergillus niger (5 μg/mL; 5 d) downregulated CDK5 expression and upregulated PP2A expression on the AD neuroglial model.
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Eur J Pharmacol
Dihydrotanshinone I potentiates the anti-tumor activity of cisplatin by activating ROS-mediated ER stress through targeting HSPD1 in lung cancer cells. [Abstract]2025 May 5:994:177378. PMID: 39952584
Catalase, Aspergillus niger purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 May 5:994:177378. [Abstract]
Catalase, Aspergillus niger (1000 unit/mL; 1.5 h) effectively attenuated the reduction in viability of H460 and H520 cells.
Catalase, Aspergillus niger purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 May 5:994:177378. [Abstract]
Catalase, Aspergillus niger (1000 unit/mL; 1.5 h) effectively increased ATF4, CHOP and p-JNK expressions in H460 and H520 cells.
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Int Immunopharmacol
Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of macrophages through mitochondrial damage by accelerating of the interaction between SCIMP and SYK pathway in acute lung injury. [Abstract]2024 Feb 15:128:111537. PMID: 38232538
Catalase, Aspergillus niger purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Feb 15:128:111537. [Abstract]
ROS inhibitor Catalase, Aspergillus niger (500 U/L; 2 h) suppressed NLRP3/Caspase-1/GSDMD protein expressions in BMDM by LPS + ATP + ApoC3.
Catalase, Aspergillus niger purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Feb 15:128:111537. [Abstract]
Catalase, Aspergillus niger (30 mg/kg; i.p.) reduced pulmonary injury and inhibited the lung injury score and W/D ratio of acute lung injury (ALI) mice.
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Solvente y solubilidad
In Vitro:
H2O : 33.33 mg/mL (Need ultrasonic)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL; Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Catalase, Aspergillus niger Related Classifications
HY-135849 Related Classifications
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