Mepyramine maleate (Standard)
Mepyramine maleate (Standard) (Pyrilamine maleate (Standard)) is the analytical standard of Mepyramine maleate (HY-B1281). This product is intended for research and analytical applications. Mepyramine maleate (Pyrilamine maleate) is a selective histamine H1 receptor antagonist and KCNQ channel inhibitor, with an IC50 of 12.5 μM against KCNQ2/Q3. Mepyramine maleate shows no activity against allergic asthma in mice when used alone, but modulates the effect of JNJ 7777120 (HY-13508) on allergic asthma in mice; it inhibits the development of morphine physical dependence and increases histamine levels in mouse brains. Mepyramine maleate can be used in studies related to seizures, convulsions, allergic asthma and morphine physical dependence.
For research use only. We do not sell to patients.
- Purity: 97%
- CAS No.: 59-33-6
- Formula: C₂₁H₂₇N₃O₅
- Molecular Weight:401.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-B1281
Mepyramine maleate
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HY-N0629
Maslinic acid
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HY-A0069
Doxylamine succinate
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HY-A0015
Bepotastine besilate
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HY-D0237
Betahistine mesylate
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HY-D0237R
Betahistine mesylate (Standard)
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HY-A0069R
Doxylamine succinate (Standard)
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HY-N0629R
Maslinic acid (Standard)
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HY-A0015R
Bepotastine besilate (Standard)
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 59-33-6
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Molecular Weight 401.46
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Formula C₂₁H₂₇N₃O₅
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SMILES
CN(C)CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=C2.O=C(O)/C=C\C(O)=O
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Synonyms
Pyrilamine maleate (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Liu B, et al. Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons. Neuropharmacology. 2008;54(4):629-639. [Content Brief]
[2]. Beermann S, et al. Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. PLoS One. 2012;7(1):e30285. [Content Brief]
[3]. Dirikolu L, et al. Pyrilamine in the horse: detection and pharmacokinetics of pyrilamine and its major urinary metabolite O-desmethylpyrilamine. J Vet Pharmacol Ther. 2009;32(1):66-78. [Content Brief]
[4]. Hui KS, et al.The effect of mepyramine on the development of morphine tolerance and physical dependence in mice. Life Sci. 1975 Sep 15;17(6):891-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mepyramine maleate (Standard) Related Classifications
HY-B1281R Related Classifications
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