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HIST2H2BE Protein, Human

Cat. No.: HY-P76381
Handling Instructions

The HIST2H2BE protein is a core component of nucleosomes, key structures in chromatin organization that wrap and compact DNA, controlling its accessibility to cellular machinery based on DNA templates. This integral role of histones, including HIST2H2BE, extends to transcriptional regulation, DNA repair, DNA replication, and chromosomal stability. HIST2H2BE Protein, Human is the recombinant human-derived HIST2H2BE protein, expressed by E. coli , with tag free. The total length of HIST2H2BE Protein, Human is 126 a.a., with molecular weight of ~16 KDa.

For research use only. We do not sell to patients.

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Description

The HIST2H2BE protein is a core component of nucleosomes, key structures in chromatin organization that wrap and compact DNA, controlling its accessibility to cellular machinery based on DNA templates. This integral role of histones, including HIST2H2BE, extends to transcriptional regulation, DNA repair, DNA replication, and chromosomal stability. HIST2H2BE Protein, Human is the recombinant human-derived HIST2H2BE protein, expressed by E. coli , with tag free. The total length of HIST2H2BE Protein, Human is 126 a.a., with molecular weight of ~16 KDa.

Background

Histone HIST2H2BE is a core component of the nucleosome, serving a pivotal role in wrapping and compacting DNA into chromatin. This compaction restricts DNA accessibility to cellular machineries, impacting crucial processes such as transcription regulation, DNA repair, DNA replication, and chromosomal stability. The regulation of DNA accessibility involves a complex interplay of post-translational modifications known as the histone code, along with nucleosome remodeling. Beyond its chromatin-associated functions, HIST2H2BE exhibits broad antibacterial activity, suggesting potential contributions to the formation of the functional antimicrobial barrier in the colonic epithelium. Additionally, this histone may play a role in the bactericidal activity of amniotic fluid, highlighting its multifaceted significance in both chromatin dynamics and host defense mechanisms against microbial threats.

Species

Human

Source

E. coli

Tag

Tag Free

Accession

Q16778 (M1-K126)

Gene ID

8349  [NCBI]

Molecular Construction
N-term
HIST2H2BE (M1-K126)
Accession # Q16778
C-term
Synonyms
Histone H2B type 2-E; Histone H2B-GL105; H2B/q; H2BC21; H2BFQ
Molecular Weight

Approximately 16 kDa.

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

HIST2H2BE Protein, Human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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HIST2H2BE Protein, Human
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HY-P76381
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