2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. NO-794

NO-794 is a histamine H2 receptor antagonist. NO-794 inhibits gastric acid secretion in pylorus-ligated rats. NO-794 can be used for the research of peptic ulcers.

For research use only. We do not sell to patients.

NO-794

NO-794 Chemical Structure

CAS No. : 105150-87-6

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Description

NO-794 is a histamine H2 receptor antagonist. NO-794 inhibits gastric acid secretion in pylorus-ligated rats. NO-794 can be used for the research of peptic ulcers[1].

IC50 & Target[1]

H2 Receptor

 

In Vitro

NO-794 (0-30 min) is a potent, time-dependent and irreversible histamine H2 receptor antagonist acting on dispersed guinea pig gastric mucosal cells, with a -log KB value of 8.4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NO-794 Related Antibodies
In Vivo

NO-794 (0.5-2 mg/kg; intradermal injection; single administration) potently inhibits gastric acid secretion in pylorus-ligated rats, with an ED50 of 0.9 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (male, 180-210 g, pylorus-ligated model)[1]
Dosage: 0.5 mg/kg; 1.0 mg/kg; 2 mg/kg
Administration: i.d.; single dose
Result: Reduced gastric acid output compared to controls at 0.5 mg/kg.
Significantly reduced gastric acid output by greater margins at 1.0 mg/kg and 2.0 mg/kg.
Achieved an ED50 value of 0.9 mg/kg for reduction of gastric acid secretion.
Demonstrated approximately 14 times more potency than ranitidine.
Molecular Weight

392.49

Formula

C23H28N4O2
CAS No.
SMILES

O=C1NC(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=C1C=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NO-794 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NO-794105150-87-6NO794NO 794Histamine Receptorhistamine H2 receptor antagonistpeptic ulcersWistarratInhibitorinhibitorinhibit

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