Zolantidine dimaleate
Based on 1 Customer Validation
Zolantidine dimaleate (SKF 95282 dimaleate) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine dimaleate induces antinociception.
For research use only. We do not sell to patients.
- Purity: 99.19%
- CAS No.: 104076-39-3
- Formula: C30H35N3O9S
- Molecular Weight:613.68
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Histamine Receptor Isoforms
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Biological Activity
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H2 Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:200-250 g, male Wistar rats (cholestatic rats)[2]
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Dosage:5, 10, 20, 40 mg/kg
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Administration:S.c.
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Result:Significantly increased tail-flick latencies and induced antinociception.
Chemical Information
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CAS No. 104076-39-3
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Appearance Solid
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Molecular Weight 613.68
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Formula C30H35N3O9S
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Color White to off-white
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SMILES
O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=CC=CC=C4S1
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Synonyms
SKF 95282 dimaleate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 33.33 mg/mL (54.31 mM; Need ultrasonic)
DMSO : 12.5 mg/mL (20.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Calcutt CR, et al. Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. Br J Pharmacol. 1988 Jan;93(1):69-78. [Content Brief]
[2]. Hasanein P. Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats. J Psychopharmacol. 2011 Feb;25(2):281-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.6295 mL | 8.1476 mL | 16.2951 mL | 40.7378 mL |
| 5 mM | 0.3259 mL | 1.6295 mL | 3.2590 mL | 8.1476 mL | |
| 10 mM | 0.1630 mL | 0.8148 mL | 1.6295 mL | 4.0738 mL | |
| 15 mM | 0.1086 mL | 0.5432 mL | 1.0863 mL | 2.7159 mL | |
| 20 mM | 0.0815 mL | 0.4074 mL | 0.8148 mL | 2.0369 mL | |
| H2O | 25 mM | 0.0652 mL | 0.3259 mL | 0.6518 mL | 1.6295 mL |
| 30 mM | 0.0543 mL | 0.2716 mL | 0.5432 mL | 1.3579 mL | |
| 40 mM | 0.0407 mL | 0.2037 mL | 0.4074 mL | 1.0184 mL | |
| 50 mM | 0.0326 mL | 0.1630 mL | 0.3259 mL | 0.8148 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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