Zolantidine (Synonyms: SK&F 95282)

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Zolantidine (SKF 95282) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine induces antinociception.

For research use only. We do not sell to patients.

Zolantidine Chemical Structure

CAS No. : 104076-38-2

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Zolantidine:

Zolantidine dimaleate

Other Forms of Zolantidine:

Zolantidine dimaleate In-stock

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
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Description

Zolantidine (SKF 95282) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine induces antinociception^[1]^[2].

IC₅₀ & Target^[1]

H₂ Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	76 μM Compound: Zolantidine	Cytotoxicity activity against human HepG2 cells after 24 hrs Cytotoxicity activity against human HepG2 cells after 24 hrs	[PMID: 20547797]

In Vivo

Zolantidine (5, 10, 20, 40 mg/kg; s.c.) induces antinociception in cholestatic rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	200-250 g, male Wistar rats (cholestatic rats)^[2]
Dosage:	5, 10, 20, 40 mg/kg
Administration:	S.c.
Result:	Significantly increased tail-flick latencies and induced antinociception.

Molecular Weight

381.53

Formula

C₂₂H₂₇N₃OS

CAS No.

104076-38-2

SMILES

C1(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=CC=CC=C4S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Calcutt CR, et al. Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. Br J Pharmacol. 1988 Jan;93(1):69-78. [Content Brief]

[2]. Hasanein P. Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats. J Psychopharmacol. 2011 Feb;25(2):281-8. [Content Brief]

Zolantidine Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zolantidine104076-38-2SK&F 95282Histamine ReceptorInhibitorinhibitorinhibit

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