1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Metiamide

Metiamide (Synonyms: SK&F 92058)

Cat. No.: HY-15540 Purity: 97.31%
Handling Instructions

Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.

For research use only. We do not sell to patients.

Metiamide Chemical Structure

Metiamide Chemical Structure

CAS No. : 34839-70-8

Size Price Stock Quantity
5 mg USD 264 In-stock
Estimated Time of Arrival: December 31
10 mg USD 443 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.

IC50 & Target

Ki: 0.92 uM (H2 receptor)

In Vitro

Metiamide (SK&F 92058) is a competitive with aldehyde substrates and noncompetitive with the Human E3 Aldehyde Dehydrogenase coenzyme, binding to both the free E3 isozyme and the enzyme·coenzyme binary complex with Ki values of 0.92 μM glycolaldehyde as the varied substrate[1]. Data is got as percentage change in GTPase activity induced by metiamide compared with the GTPase activity stimulated by HA (100 μM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

244.38

Formula

C₉H₁₆N₄S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 2.4 mg/mL (9.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0920 mL 20.4599 mL 40.9199 mL
5 mM 0.8184 mL 4.0920 mL 8.1840 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Metiamide
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