NME2 Antibody (YA3884)
(Synonyms: PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2)NME2 Antibody (YA3884) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NME2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:200-1:1000 | 1:10000 |
Product Details
NME2 Antibody (YA3884) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NME2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 17 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 17 kDa
Purified recombinant fragment of human NME2 (AA: FULL(1-152)) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NME2 is a Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity[1][2][3][4][5].
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Subcellular Localization
Cytoplasm; Cell projection, lamellipodium; Cell projection, ruffle; Cytoplasm; Cytoplasm, perinuclear region; Nucleus; Cytoplasm; Cytoplasm, perinuclear region; Nucleus
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Expression
Tissue_specificity:Universal expression; universal expression -
Isoforms & Post-Translational Modification
P22392 has 2 isomers: P22392-1: 17298 Da (predicted); P22392-2: 30137 Da (predicted).
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Subunit
Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6) (PubMed:1851158). Interacts with CAPN8 (By similarity). Interacts with AKAP13 (PubMed:15249197). Interacts with ITGB1BP1 (via C-terminal domain region) (PubMed:11919189). Interacts with BCL2L10 (PubMed:17532299)
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SwissProt ID
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Synonyms
PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
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