EGFR-IN-197

EGFR-IN-197 (compound 6e) (72 h) potently inhibits proliferation of NCI-H1975, HCC827, and A431 cells with IC₅₀ values of 0.0473 μM, 0.0185 μM, and 0.0226 μM, respectively^[1].
EGFR-IN-197 potently inhibits EGFR^L858R/T790M and EGFR^{L858R/T790M/C797S} mutant kinases with IC₅₀ values of 19.5 nM and 12.0 nM, respectively^[1].
EGFR-IN-197 (0.05-0.5 μM; 14 d) concentration-dependently inhibits colony formation of NCI-H1975 cells^[1].
EGFR-IN-197 (0.05-0.5 μM; 12 h, 24 h) concentration-dependently inhibits migration of NCI-H1975 cells^[1].
EGFR-IN-197 (0.05-0.5 μM, 24 h) disrupts mitochondrial translocation of EGFR in NCI-H1975 cells^[1].
EGFR-IN-197 (0.05-0.5 μM, 24 h) concentration-dependently upregulates mitochondrial H₂S levels in NCI-H1975 cells^[1].
EGFR-IN-197 (0.005-0.5 μM; 24 h) concentration-dependently inhibits phosphorylation of EGFR and ERK1/2 in NCI-H1975 cells, and significantly inhibits AKT phosphorylation at 0.5 μM^[1].
EGFR-IN-197 (0.005-0.5 μM; 24 h) concentration-dependently modulates apoptosis-related proteins in NCI-H1975 cells, increasing Cleaved PARP and Cleaved caspase-3 and decreasing Bcl-xL^[1].
EGFR-IN-197 (0.1-1 μM; 24 h) concentration-dependently induces apoptosis in NCI-H1975 cells, with strong induction of late apoptosis at 0.5 μM and above^[1].
EGFR-IN-197 (0.05-0.5 μM; 24 h) concentration-dependently arrests NCI-H1975 cells at the G2/M phase, with 62.29% of cells in G2/M phase at 0.5 μM^[1].
EGFR-IN-197 (0.05-0.5 μM; 72 h) induces DNA damage in NCI-H1975 cells in a concentration-dependent manner, with significant damage observed at 0.1 μM and above^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.