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Cat. No.: HY-121777

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SFOM-0046

SFOM-0046 arrests cell cycle in S-phase and causes DNA replication stress leading to the phosphorylation of H2AX into γ-H2AX. SFOM-0046 induces DNA damages. SFOM-0046 is a potent anticancer agent.

For research use only. We do not sell to patients.

CAS No.: 1383607-61-1
Formula: C₁₇H₂₀N₂O₄S
Molecular Weight:348.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

SFOM-0046 Chemical Structure

CAS No.: 1383607-61-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	0.36 μM Compound: SFOM-0046	Antiproliferative activity against human HT1080 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT1080 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 26408815]
HT-1080	IC₅₀	0.45 μM Compound: SFOM-0046	Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]
HT-1080	IC₅₀	7.4 μM Compound: SFOM-0046	Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay	[PMID: 33007554]
HT-29	IC₅₀	0.99 μM Compound: SFOM-0046	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]
HT-29	IC₅₀	12 μM Compound: 46	Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay	[PMID: 22694057]
HT-29	IC₅₀	12 μM Compound: SFOM-0046	Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 26408815]
HT-29	IC₅₀	27 μM Compound: SFOM-0046	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay	[PMID: 33007554]
M21	IC₅₀	2.5 μM Compound: 46	Cytotoxicity against human M21 cells after 48 hrs by SRB assay Cytotoxicity against human M21 cells after 48 hrs by SRB assay	[PMID: 22694057]
M21	IC₅₀	2.5 μM Compound: SFOM-0046	Antiproliferative activity against human M21 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human M21 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 26408815]
M21	IC₅₀	3 μM Compound: SFOM-0046	Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]
M21	IC₅₀	30 μM Compound: SFOM-0046	Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay	[PMID: 33007554]
MCF7	IC₅₀	18 μM Compound: SFOM-0046	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay	[PMID: 33007554]
MCF7	IC₅₀	3.4 μM Compound: 46	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 22694057]
MCF7	IC₅₀	3.4 μM Compound: SFOM-0046	Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 26408815]
MCF7	IC₅₀	5.9 μM Compound: SFOM-0046	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]
Panel colon (Carcinoma cell lines)	IC₅₀	1.5 μM Compound: SFOM-0046	Antiproliferative activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]
Panel colon cells	IC₅₀	1.5 μM Compound: SFOM-0046	Antiproliferative activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]
Panel leukemia (Carcinoma cell lines)	IC₅₀	0.81 μM Compound: SFOM-0046	Antiproliferative activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]
Panel leukemia cells	IC₅₀	0.81 μM Compound: SFOM-0046	Antiproliferative activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]
Panel NCI-60 (60 carcinoma cell lines)	IC₅₀	3.5 μM Compound: SFOM-0046	Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]
Panel NCI-60 cells	IC₅₀	3.5 μM Compound: SFOM-0046	Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 33007554]

Chemical Information

CAS No. 1383607-61-1
Molecular Weight 348.42
Formula C₁₇H₂₀N₂O₄S
SMILES

O=S(C1=CC=C(C=C1)NC(NCC)=O)(OC2=CC=CC=C2CC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Joris Pauty, et al. Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks. Sci Rep. 2016 Mar 22:6:23302. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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