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  2. IRBP (1-20), human TFA

IRBP (1-20), human TFA 

Cat. No.: HY-P1587A
Handling Instructions

IRBP (1-20), human TFA contains a major epitope for the H-2b haplotype. IRBP (1-20), human TFA induces experimental autoimmune uveoretinitis (EAU) in H-2b mice.

For research use only. We do not sell to patients.

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IRBP (1-20), human TFA Chemical Structure

IRBP (1-20), human TFA Chemical Structure

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Description

IRBP (1-20), human TFA contains a major epitope for the H-2b haplotype. IRBP (1-20), human TFA induces experimental autoimmune uveoretinitis (EAU) in H-2b mice[1][2].

In Vivo

IRBP (1-20), human TFA induces EAU[2].
For determination of proliferative and cytokine responses, lymph node and spleen cells are collected 21 days after immunization and are stimulated in culture with the appropriate antigen. Cells of C57BL/6 mice and 129/J mice immunized with IRBP (1-20), human TFA proliferated in response to the peptide[2].

Animal Model: C57BL/6 (H-2b) mice, H-2b (C57BL/6, 129/J) mice[2]
Dosage: 200, 300 μg
Administration: I.h.; After 21 days
Result: C57BL/6 (H-2b) mice immunized with the human peptide (200-300 μg= 80-120 nmoles) developed EAU. 129/J mice (H-2b) also developed disease, albeit with a lower average score than C57BL/6.
Molecular Weight

2308.62

Formula

C₁₀₃H₁₆₅F₃N₂₄O₃₀S

Sequence

Gly-Pro-Thr-His-Leu-Phe-Gln-Pro-Ser-Leu-Val-Leu-Asp-Met-Ala-Lys-Val-Leu-Leu-Asp

Sequence Shortening

GPTHLFQPSLVLDMAKVLLD

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IRBP (1-20), humanOthersexperimentalautoimmuneuveoretinitisEAUH-2bepitopediseaseC57BL/6 miceInhibitorinhibitorinhibit

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IRBP (1-20), human TFA
Cat. No.:
HY-P1587A
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