2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Ifetroban sodium

Ifetroban sodium  (Synonyms: BMS-180291 sodium)

Cat. No.: HY-105218A Purity: 99.24%
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Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research.

For research use only. We do not sell to patients.

Ifetroban sodium Chemical Structure

Ifetroban sodium Chemical Structure

CAS No. : 156715-37-6

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1 mg USD 280 In-stock
5 mg USD 820 In-stock
10 mg USD 1320 In-stock
25 mg USD 2650 In-stock
50 mg USD 4250 In-stock
100 mg USD 6800 In-stock
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Based on 1 publication(s) in Google Scholar

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Ifetroban sodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ifetroban sodium

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Description

Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research[1][2][3][4].

IC50 & Target

Thromboxane A2 receptor; Prostaglandin H2 receptor[4]
In Vitro

Ifetroban sodium (CPI211) (100 nM; 48 h) results Tpr inhibition and potently blocks spontaneous metastasis from primary tumors, without affecting tumor cell proliferation, motility, or tumor growth in 4T1 cells (mouse mammary cancer)[2].
Ifetroban sodium (100 nM; 6 h) strongly inhibits PKC substrate phosphorylation, and blocks agonist (U46619, HY-108566)-induced TPr diminution in human umbilical vein endothelial cells (HUVECs)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ifetroban sodium Related Antibodies

Western Blot Analysis[2]

Cell Line: Mouse pulmonary microvascular endothelial cells (MPMECs) and human umbilical vein endothelial cells (HUVECs)
Concentration: 100 nM
Incubation Time: 6 hours
Result: Decreased the level of TPr protein and inhibited PKC substrate phosphorylation.

Immunofluorescence[2]

Cell Line: Mouse pulmonary microvascular endothelial cells (MPMECs) and human umbilical vein endothelial cells (HUVECs)
Concentration: 100 nM
Incubation Time: 6 hours
Result: Showed transendothelial migration of GFP+ 4T1 and MDA-MB-231 across mouse MPMECs and human HUVECs.
In Vivo

Ifetroban sodium (50 mg/kg/d; p.o.; 2 d prior to, through 28 d after tumor injection) decreases hematogenous metastasis of multiple cancer types without in mice model[2].
Ifetroban sodium (50 mg/kg/d; p.o.; 12 d) does not affect primary tumor growth but decreases tumor vessels in mice with 4T1 (mouse mammary cancer)[2].
Ifetroban sodium (BMS 180,291; 1 and 3 mg/kg, p.o.) inhibits aggregation and antagonizes TP-receptor in monekys. Ifetroban sodium (3 mg/kg, i.v.) causes only marginal and transient hemodynamic effects in anesthetized African green monkeys[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic (nu/nu) Balb/C female mice injected with tumor cells: 4T1 (mouse mammary cancer), MDA-MB-231 (human breast cancer), MiaPaCa2 (human pancreatic cancer), and A549 (human lung cancer) model[2]
Dosage: 50 mg/kg; via 25 μL vehicle (4% sucrose in sterile water)
Administration: Oral gavage; pretreated before 2 days and treated 28 days later
Result: Decreased the percentage of mice harboring MDA-MB-231 lung metastases from 90% to 20%, and mice with A549 lung metastases from 60% to 10%.
Clinical Trial
Molecular Weight

462.51

Formula

C25H31N2NaO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CCC(C=CC=C1)=C1C[C@@H]2[C@H](C3=NC(C(NCCCCC)=O)=CO3)[C@@H]4O[C@H]2CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (281.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1621 mL 10.8106 mL 21.6212 mL
5 mM 0.4324 mL 2.1621 mL 4.3242 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1621 mL 10.8106 mL 21.6212 mL 54.0529 mL
5 mM 0.4324 mL 2.1621 mL 4.3242 mL 10.8106 mL
10 mM 0.2162 mL 1.0811 mL 2.1621 mL 5.4053 mL
15 mM 0.1441 mL 0.7207 mL 1.4414 mL 3.6035 mL
20 mM 0.1081 mL 0.5405 mL 1.0811 mL 2.7026 mL
25 mM 0.0865 mL 0.4324 mL 0.8648 mL 2.1621 mL
30 mM 0.0721 mL 0.3604 mL 0.7207 mL 1.8018 mL
40 mM 0.0541 mL 0.2703 mL 0.5405 mL 1.3513 mL
50 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0811 mL
60 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9009 mL
80 mM 0.0270 mL 0.1351 mL 0.2703 mL 0.6757 mL
100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.5405 mL
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Ifetroban sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ifetroban156715-37-6BMS-180291BMS180291BMS 180291Prostaglandin Receptormyocardial ischemiahypertensionstrokethrombosiscardiomyopathyantiplateletmigration inhibitonInhibitorinhibitorinhibit

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