2. Anti-infection
  3. Influenza Virus
  4. Diridavumab

Diridavumab  (Synonyms: CR6261)

Cat. No.: HY-P99853 Purity: 98.09%
COA

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Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus.

For research use only. We do not sell to patients.

Diridavumab Chemical Structure

Diridavumab Chemical Structure

CAS No. : 1393659-46-5

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Based on 1 publication(s) in Google Scholar

Diridavumab Related Antibodies

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Description

Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus[1].

In Vitro

Diridavumab (CR6261; 500 μg/mL) neutralized AA60 and Sw06 with 39.4 μg/mL and 176.8μg/mL, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diridavumab Related Antibodies
In Vivo

Diridavumab (CR6261; 1.7-15 mg/kg; i.p.; BALB/c mice with H2 influenza virus) protects mice against lethal H2 influenza virus in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with H2 influenza virus[1]
Dosage: 1.7, 5, or 15 mg/kg
Administration: Intraperitoneal injection
Result: Prevented mortality and decreased the percent weight loss.
Decreased viral load, altered antigen distribution, and reduced the severity of airway inflammation.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Diridavumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.09%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Diridavumab Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diridavumab1393659-46-5CR6261CR 6261CR-6261Influenza VirusHApH-dependent fusioncellularviral membranesendosomeInhibitorinhibitorinhibit

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