IT 066 hydrochloride
IT 066 hydrochloride is a Histamine H2 receptor antagonist. IT 066 hydrochloride possesses antioxidant activity and can protect rats against acute gastric mucosal injury induced by ischemia-reperfusion. IT 066 hydrochloride can also inhibit secretagogue-induced gastric acid secretion in rats and exert a long-acting anti-lesion effect on experimental gastric and duodenal lesions in rats. IT 066 hydrochloride is applicable for the research of gastrointestinal diseases.
For research use only. We do not sell to patients.
- CAS No.: 126463-66-9
- Formula: C19H25ClN4O3
- Molecular Weight:392.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
Chemical Information
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CAS No. 126463-66-9
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Molecular Weight 392.88
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Formula C19H25ClN4O3
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SMILES
O=C1C(C(N)=C1NC/C=C\COC2=NC=CC(CN3CCCCC3)=C2)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Naito Y, et al. Effect of a novel histamine H2 receptor antagonist, IT-066, on acute gastric injury induced by ischemia-reperfusion in rats, and its antioxidative properties. Eur J Pharmacol. 1995 Dec 27;294(1):47-54. [Content Brief]
[2]. Isobe Y, et al. Antisecretory and antilesional effect of a new histamine H2-receptor antagonist, IT-066, in rats. J Pharmacol Exp Ther. 1990 Dec;255(3):1078-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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