126463-66-9
Chemical Structure
IT 066 hydrochloride
- CAS No.: 126463-66-9
- Formula:C19H25ClN4O3
- Molecular Weight:392.88
IUPAC Name: (Z)-3-amino-4-((4-((4-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)amino)cyclobut-3-ene-1,2-dione hydrochloride
InChIKey: ODBOENMSSFCACZ-PVOKDAACSA-N
SMILES: O=C1C(C(N)=C1NC/C=C\COC2=NC=CC(CN3CCCCC3)=C2)=O.Cl
Biological Activity: IT 066 hydrochloride is a Histamine H2 receptor antagonist. IT 066 hydrochloride possesses antioxidant activity and can protect rats against acute gastric mucosal injury induced by ischemia-reperfusion. IT 066 hydrochloride can also inhibit secretagogue-induced gastric acid secretion in rats and exert a long-acting anti-lesion effect on experimental gastric and duodenal lesions in rats. IT 066 hydrochloride is applicable for the research of gastrointestinal diseases[1][2].
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IT 066 hydrochloride | IT 066 hydrochloride is a Histamine H2 receptor antagonist. IT 066 hydrochloride possesses antioxidant activity and can protect rats against acute gastric mucosal injury induced by ischemia-reperfusion. IT 066 hydrochloride can also inhibit secretagogue-induced gastric acid secretion in rats and exert a long-acting anti-lesion effect on experimental gastric and duodenal lesions in rats. IT 066 hydrochloride is applicable for the research of gastrointestinal diseases. | |||||||||||||||||||||
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References
- [1]. Naito Y, et al. Effect of a novel histamine H2 receptor antagonist, IT-066, on acute gastric injury induced by ischemia-reperfusion in rats, and its antioxidative properties. Eur J Pharmacol. 1995 Dec 27;294(1):47-54. [Content Brief]
- [2]. Isobe Y, et al. Antisecretory and antilesional effect of a new histamine H2-receptor antagonist, IT-066, in rats. J Pharmacol Exp Ther. 1990 Dec;255(3):1078-82. [Content Brief]
