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AP39 

Cat. No.: HY-126124 Purity: 95.08%
Handling Instructions

AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. AP39 increases intracellular H2S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury and protects against Alzheimer's disease in mice model.

For research use only. We do not sell to patients.

AP39 Chemical Structure

AP39 Chemical Structure

CAS No. : 1429061-80-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 159 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
25 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. AP39 increases intracellular H2S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury and protects against Alzheimer's disease in mice model[1][2][3].

In Vitro

AP39 (25,100 nM; for 24 h) results in increase in cell viability in APP/PS1 neurons and has no effect on cell viability in WT neurons[1].
AP39 (100 nM) increases the levels of OPA1 and Mfn1 but not Mfn2. Moreover, AP39 decreases the levels of Fis1 but not Drp1[1].
AP39 (25-250 nM; 2 h) induces a concentration-dependent increase in H2S generation and in the fluorescence of the H2S-detecting dye AzMC[1].
AP39 (100 nM) significantly increases the basal respiratory rate and the OCR-linked maximal respiratory capacity of the APP/PS1 neurons. AP39 significantly increases the ATP production in WT and APP/PS1 neurons. AP39 significantly protects against mtDNA damage in APP/PS1 neurons by partially restoring mtDNA integrity[1].
AP39 consists of a mitochondria-targeting motif, triphenylphosphonium (TPP+), coupled to a H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (100 nM) reduces intracellular oxidative stress and in the meantime it consequently sustaines the cell viability, mitochondrial respiration and mitochondrial DNA integrity. These effects tend to be stimulatory at lower concentrations (30 and 100 nM), but tend to diminish or convert into inhibitory effects at a higher concentration (300 nM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AP39 (100 nM/kg/day; ip; for 6 weeks) ameliorates the learning and memory deficits of APP/PS1 mice. AP39 (25-250 nM/kg/day; ip; for 6 weeks) induces a dose-dependent increase in H2S generation in the cortex and hippocampus of WT and APP/PS1 mice[1].
AP39 (0.01, 0.1, 1 μmol/kg; iv; bolus 10 min before reperfusion) dose‐dependently reduces infarct size anaesthetized by thiobutabarbital (200 mg/kg, i.p) in male Sprague Dawley rats, 300-350 g (9-11 weeks)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 12-month-old WT or APP/PS1 mice[1]
Dosage: 100 nM/kg
Administration: IP; daily; for 6 weeks
Result: Reversed the spatial learning and memory deficits of the aged AD model mice.
Alleviated brain atrophy and ventricle asymmetryand inhibited Aβ plaque deposition in the brains in AD model mice.
Molecular Weight

721.77

Formula

C₃₇H₃₈BrO₂PS₃

CAS No.

1429061-80-2

SMILES

S=C1SSC(C2=CC=C(OC(CCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)C=C2)=C1.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (138.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3855 mL 6.9274 mL 13.8548 mL
5 mM 0.2771 mL 1.3855 mL 2.7710 mL
10 mM 0.1385 mL 0.6927 mL 1.3855 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (1.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (1.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AP39AP 39AP-39OthersmitochondriahydrogensulfideH2SdonorcytoprotectiveDNAAPP/PS1OPA1Mfn1Mfn2mtDNAInhibitorinhibitorinhibit

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Product Name:
AP39
Cat. No.:
HY-126124
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