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MitoPQ  (Synonyms: MitoParaquat)

Cat. No.: HY-130278 Purity: 99.92%
COA Handling Instructions

MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study.

For research use only. We do not sell to patients.

MitoPQ Chemical Structure

MitoPQ Chemical Structure

CAS No. : 1821370-28-8

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10 mg USD 190 In-stock
25 mg USD 290 In-stock
50 mg USD 460 In-stock
100 mg USD 735 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study[1].

In Vitro

MitoPQ (5 μM, 0.5 s-20 min) increases MitoSOX fluorescence in dose- and time-dependently manner in C2C12 myoblasts[1].
MitoPQ (1-10 μM, 6 h) increases MnSOD expression at the dose of 1-5 μM and decreases MnSOD expression at the dose of 10 μM in C2C12 myoblasts[1].
MitoPQ (1-10 μM, 24 h) increased HCT-116 cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

954.48

Formula

C39H46I3N2P

CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (52.38 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (34.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0477 mL 5.2385 mL 10.4769 mL
5 mM 0.2095 mL 1.0477 mL 2.0954 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.92%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.0477 mL 5.2385 mL 10.4769 mL 26.1923 mL
5 mM 0.2095 mL 1.0477 mL 2.0954 mL 5.2385 mL
10 mM 0.1048 mL 0.5238 mL 1.0477 mL 2.6192 mL
15 mM 0.0698 mL 0.3492 mL 0.6985 mL 1.7462 mL
20 mM 0.0524 mL 0.2619 mL 0.5238 mL 1.3096 mL
25 mM 0.0419 mL 0.2095 mL 0.4191 mL 1.0477 mL
30 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.8731 mL
H2O 40 mM 0.0262 mL 0.1310 mL 0.2619 mL 0.6548 mL
50 mM 0.0210 mL 0.1048 mL 0.2095 mL 0.5238 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MitoPQ Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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