MitoPQ
Based on 5 publication(s) in Google Scholar
MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study.
For research use only. We do not sell to patients.
- Purity: 99.14%
- CAS No.: 1821370-28-8
- Formula: C39H46I3N2P
- Molecular Weight:954.48
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
Protein Tyrosine Kinase Compound Library
HY-L016
-
Anti-Cancer Compound Library
HY-L025
-
Antioxidant Compound Library
HY-L037
-
Membrane Protein-targeted Compound Library
HY-L149
-
Highly Selective Activators Library
HY-L159
-
Radioprotector Library
HY-L178
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Anti-Fibrosis Compound Library
HY-L185
-
Protein Kinase Compound Library
HY-L196
-
High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) MitoPQ
More
Customer Validation & Images
-
Cell Imaging/Staining
-
Cell Imaging/Staining
-
RT-PCR
-
Bio/Physico-chemical Assay
-
2D/3D Cell Culture and Differentiation
Biological Activity
MitoPQ (5 μM, 0.5 s-20 min) increases MitoSOX fluorescence in dose- and time-dependently manner in C2C12 myoblasts[1].
MitoPQ (1-10 μM, 6 h) increases MnSOD expression at the dose of 1-5 μM and decreases MnSOD expression at the dose of 10 μM in C2C12 myoblasts[1].
MitoPQ (1-10 μM, 24 h) increased HCT-116 cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1821370-28-8
-
Appearance Solid
-
Molecular Weight 954.48
-
Formula C39H46I3N2P
-
Color Brown to reddish brown
-
SMILES
C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]
-
Synonyms
MitoParaquat
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Cell Res
Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses. [Abstract]2025 Feb;35(2):97-116. PMID: 39757301 -
Sci Adv
Mitochondrial ROS trigger interorganellular signaling and prime ER processes to establish enhanced plant immunity. [Abstract]2025 Oct 3;11(40):eady9234. PMID: 41032619
MitoPQ purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Oct 3;11(40):eady9234. [Abstract]
MitoPQ (0.5 μM, ~1 h) induced mitochondrial ROS in Arabidopsis Col-0 expressing ER-lumen-targeted cyan fluorescent protein.
MitoPQ purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Oct 3;11(40):eady9234. [Abstract]
MitoPQ (0.5 μM, 3 h) enhanced ER-mitochondria association in Arabidopsis root cells.
MitoPQ purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Oct 3;11(40):eady9234. [Abstract]
MitoPQ (0.5 μM, 8 h) up-regulated UPR marker genes in 10-day-old Col-0 Arabidopsis seedlings, but subsequent BA treatment down-regulated their expression.
-
Redox Biol
Inhibition of mitochondrial complex I leading to NAD+/NADH imbalance in type 2 diabetic patients who developed late stent thrombosis: Evidence from an integrative analysis of platelet bioenergetics and metabolomics. [Abstract]2022 Nov:57:102507. PMID: 36244294
MitoPQ purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Nov:57:102507. [Abstract]
MitoParaquat (0.1 μM, 30 min) abolished the inhibition of platelet aggregation by nicotinamide riboside (1 mM, 30 min) or olaparib (20 μM, 30 min) in resting platelets from LST patients.
MitoPQ purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Nov:57:102507. [Abstract]
MitoParaquat (0.1 μM, 30 min) did not interrupt the improvements in mitochondrial respiration induced by nicotinamide riboside (1 mM) or olaparib (20 μM) in resting platelets from LST patients.
-
-
PLoS Pathog
2024 Nov 5;20(11):e1012614. PMID: 39499730
Solvent & Solubility
H2O : 50 mg/mL (52.38 mM; Need ultrasonic)
DMSO : 33.33 mg/mL (34.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (1.05 mM); Clear solution
This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (1.05 mM); Clear solution
This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Portuguese - PT (480 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.0477 mL | 5.2385 mL | 10.4769 mL | 26.1923 mL |
| 5 mM | 0.2095 mL | 1.0477 mL | 2.0954 mL | 5.2385 mL | |
| 10 mM | 0.1048 mL | 0.5238 mL | 1.0477 mL | 2.6192 mL | |
| 15 mM | 0.0698 mL | 0.3492 mL | 0.6985 mL | 1.7462 mL | |
| 20 mM | 0.0524 mL | 0.2619 mL | 0.5238 mL | 1.3096 mL | |
| 25 mM | 0.0419 mL | 0.2095 mL | 0.4191 mL | 1.0477 mL | |
| 30 mM | 0.0349 mL | 0.1746 mL | 0.3492 mL | 0.8731 mL | |
| H2O | 40 mM | 0.0262 mL | 0.1310 mL | 0.2619 mL | 0.6548 mL |
| 50 mM | 0.0210 mL | 0.1048 mL | 0.2095 mL | 0.5238 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Powered by Bioz