2. Apoptosis
  3. Bcl-2 Family
  4. IB001

IB001 is a humanized anti-BAG3 antibody that inhibits BAG3, with a KD value of 14.4 nM for human BAG3. IB001 blocks BAG3-dependent monocyte/macrophage activation, interferes with the interaction between BAG3 and IFITM-2, and disrupts tumor microenvironment signaling pathways. IB001 inhibits tumor growth, reduces α-SMA-positive fibroblasts, and blocks BAG3-dependent IL-6 release. IB001 accumulates in a time-dependent manner in pancreatic ductal adenocarcinoma tumors. IB001 can be used for research related to pancreatic ductal adenocarcinoma.

For research use only. We do not sell to patients.

IB001

IB001 Chemical Structure

Size Stock
1 mg   Get quote  
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

IB001 Related Antibodies

Top Publications Citing Use of Products

View All Bcl-2 Family Isoform Specific Products:

View All Isoforms
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

IB001 is a humanized anti-BAG3 antibody that inhibits BAG3, with a KD value of 14.4 nM for human BAG3. IB001 blocks BAG3-dependent monocyte/macrophage activation, interferes with the interaction between BAG3 and IFITM-2, and disrupts tumor microenvironment signaling pathways. IB001 inhibits tumor growth, reduces α-SMA-positive fibroblasts, and blocks BAG3-dependent IL-6 release. IB001 accumulates in a time-dependent manner in pancreatic ductal adenocarcinoma tumors. IB001 can be used for research related to pancreatic ductal adenocarcinoma[1].

Species Reactivity

Human
IC50 & Target[1]

HSP70

 

In Vitro

IB001 (BAG3-H2L4) binds to purified recombinant human BAG3 protein with a Kd of 14.4 nM[1].
IB001 inhibits binding of FITC-labeled recombinant human BAG3 to murine J774A.1 macrophage cells[1].
IB001 (9.37-300 μg/mL; 16 h) dose-dependently inhibits recombinant human BAG3-induced IL-6 production by isolated human CD14+ monocytes[1].
IB001 (200 μg/mL; 16 h) significantly inhibits PANC-1 pancreatic cancer cell conditioned medium-induced IL-6 production by isolated human CD14+ monocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IB001 Related Antibodies
In Vivo

IB001 (BAG3-H2L4) (20 mg/kg; every 48 h; twice a week) induces significant pancreatic ductal adenocarcinoma tumor growth inhibition and reduces α-SMA-positive fibroblast abundance in tumor tissue in female CD-1 nu/nu mice[1].
IB001 (20 mg/kg; daily; 7 days) does not induce cardiotoxicity in 6-month-old athymic nude-Foxn1 nu/nu mice after 7 days of daily treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 nu/nu (female, 6 weeks old, injected with MIA PaCa-2 cells)[1]
Dosage: 20 mg/kg
Administration: every 48 h; twice a week
Result: Achieved significant tumor growth inhibition, with final tumor volume reaching ~400% of initial volume compared to ~1000% in vehicle controls.
Reduced α-SMA-positive fibroblast area in tumor tissue from ~3.5% in vehicle-treated mice to <0.5%.
Animal Model: Athymic nude-Foxn1 nu/nu (6 months old)[1]
Dosage: 20 mg/kg
Administration: daily; 7 days
Result: Showed no adverse effect on ejection fraction, shortening fraction, or strain percentage.
Gene ID

9531  [NCBI]

Accession

O95817
Target

BAG3
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

IB001 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IB001BAG3-H2L4IB 001IB-001Bcl-2 Familyfemale CD-1 nu/nu micePANC-1 pancreatic cancer cellIFITM-2monocyte/macrophagealpha-SMA-positive fibroblastshuman CD14+ monocytesIL-6murine J774A.1 macrophage cellspancreatic ductal adenocarcinomahuman BAG3Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
IB001
Cat. No.:
HY-P992379
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.