2. Others
  3. Drug Intermediate
  4. HOOC-OXA-COOH

HOOC-OXA-COOH is an anionic prodrug of Oxaliplatin (HY-17371). HOOC-OXA-COOH can be loaded onto nanomotors via electrostatic interaction, and undergoes cascade activation by H2S and endogenous glutathione in the tumor microenvironment to release cytotoxic Pt2+. HOOC-OXA-COOH can be used in the research of colon cancer.

For research use only. We do not sell to patients.

HOOC-OXA-COOH

HOOC-OXA-COOH Chemical Structure

CAS No. : 1002788-96-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

HOOC-OXA-COOH Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HOOC-OXA-COOH is an anionic prodrug of Oxaliplatin (HY-17371). HOOC-OXA-COOH can be loaded onto nanomotors via electrostatic interaction, and undergoes cascade activation by H2S and endogenous glutathione in the tumor microenvironment to release cytotoxic Pt2+. HOOC-OXA-COOH can be used in the research of colon cancer[1].

In Vitro

HOOC-OXA-COOH is released from F1O LNM1-RGD nanomotors in an H2S concentration-dependent manner, and nearly complete release is achieved after treatment with 150 μM NaHS for 3 h[1].
HOOC-OXA-COOH (48 h) delivered by F1O LNM1-RGD potently inhibits the viability of CT26 cells, with an IC50 of 24.9 μM, while irradiation with 780 nm laser further reduces the IC50 to 5.92 μM; this formulation shows low toxicity to HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HOOC-OXA-COOH Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: CT26 mouse colorectal carcinoma cells, HEK293 human embryonic kidney cells
Concentration: /
Incubation Time: 48 h
Result: Exhibited an IC50 of 24.9 μM against CT26 cells when delivered via F1O LNM1-RGD, which was significantly lower than the IC50 of free HOOC-OXA-COOH (151.8 μM) against CT26 cells.
Showed an even lower IC50 of 5.92 μM against CT26 cells when F1O LNM1-RGD was combined with 780 nm laser irradiation.
Resulted in significantly higher viability in HEK293 cells compared to CT26 cells when delivered via F1O LNM1-RGD.
In Vivo

HOOC-OXA-COOH (2.5 mg/kg calculated as Pt; intravenous injection; 4 administrations), when delivered via F1O LNM1-RGD, inhibits mouse CT26 colon tumors upon combined irradiation with 780 nm laser[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (tumor-bearing)[1]
Dosage: 2.5 mg/kg Pt (equivalent to HOOC-OXA-COOH loading)
Administration: i.v.; on day 0, 2, 4, and 6; with or without 780 nm laser irradiation (5 min, 0.5 W cm-2) 1 hour post-injection on the same days
Result: Eradicated subcutaneous CT26 colon tumors when combined with light treatment.
Significantly prolonged survival rate compared to control groups.
Induced stronger immunogenic cell death effects than free OXA.
Significantly upregulated pro-inflammatory cytokine levels (TNF-α, IL-6, IFN-γ) in tumor tissues and increased dendritic cell maturation in draining lymph nodes, with greater effects seen with light treatment.
Enhanced intratumoral infiltration of CD4+ and CD8+ cytotoxic T lymphocytes, while reduced regulatory T cell populations; light treatment amplified these changes.
Induced robust immune memory.
Molecular Weight

629.44

Formula

C16H22N2O12Pt2-
CAS No.
SMILES

[O-]C(CCC([O-][Pt+4]12([NH2][C@@]3([H])[C@](CCCC3)([H])[NH2]1)([O-]C(C([O-]2)=O)=O)[O-]C(CCC([O-])=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

HOOC-OXA-COOH Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HOOC-OXA-COOH1002788-96-6Drug IntermediateDrug Iintermediateadaptive immune responsesorthotopic CT26 colon tumorhepatic metastasisantitumor immune memoryHEK293 cellssubcutaneous CT26 colon tumorsCT26 MCTSCT26 cellcolon cancerimmunogenic cell deathInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
HOOC-OXA-COOH
Cat. No.:
HY-186158
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.