2. Stem Cell/Wnt
  3. Hippo (MST)
  4. BRD2577

BRD2577 is a selective mercaptopyruvate sulfurtransferase (3-MST) inhibitor with an IC50 of 9.9 μM. BRD2577 inhibits H2S production in colon carcinoma cells. BRD2577 exhibits weak to no significant inhibitory effect on colon cancer cell proliferation and mitochondrial activity. BRD2577 can be used for the research of colon cancer.

For research use only. We do not sell to patients.

BRD2577

BRD2577 Chemical Structure

CAS No. : 353781-42-7

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Based on 1 publication(s) in Google Scholar

BRD2577 Related Antibodies

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Description

BRD2577 is a selective mercaptopyruvate sulfurtransferase (3-MST) inhibitor with an IC50 of 9.9 μM. BRD2577 inhibits H2S production in colon carcinoma cells. BRD2577 exhibits weak to no significant inhibitory effect on colon cancer cell proliferation and mitochondrial activity. BRD2577 can be used for the research of colon cancer[1].

IC50 & Target[1]

MST3

9.9 μM (IC50)

In Vitro

BRD2577 (Compound 13a) (3-300 μM; 1 h) potently inhibits recombinant human 3-MST with an IC50 of 9.9 μM and achieves ≥60% inhibition at 100 μM, and shows no activity against human recombinant CBS or CSE at concentrations up to 300 μM[1].
BRD2577 (300 μM; 2 h) does not act as an H2S scavenger at 300 μM, confirming its inhibitory effect is direct against 3-MST[1].
BRD2577 (300 μM; 4 h) inhibits H2S production in live murine CT26 and MC38 colon carcinoma cells[1].
BRD2577 (3-300 μM; 48 h) does not significantly inhibit the proliferation of murine CT26 or MC38 colon carcinoma cells at concentrations up to 300 μM after 48 h of treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRD2577 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Murine CT26 colon carcinoma cells, murine MC38 colon carcinoma cells
Concentration: 3, 10, 30, 100, 300 μM
Incubation Time: 48 h
Result: Did not significantly inhibit CT26 or MC38 cell proliferation at tested concentrations.
Showed an IC50 values were >1000 μM for both cell lines.
Molecular Weight

317.36

Formula

C15H15N3O3S
CAS No.
SMILES

O=C1N=C(SCC(=O)C2=CC=C(C=C2)NC(=O)C)NC(=C1)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRD2577 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD2577353781-42-7BRD 2577BRD-2577Hippo (MST)3-MSTcolon cancer cellH2S productioncystathionine-β-synthasemitochondrial activityMC38colon cancerCT263-mercaptopyruvate sulfurtransferasecystathionine-γ-lyaseInhibitorinhibitorinhibit

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