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Cat. No.: HY-150563

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Neuroinflammatory-IN-2

Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC₅₀ value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ_1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H₂O₂-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease.

For research use only. We do not sell to patients.

CAS No.: 2361384-14-5
Formula: C₂₅H₂₇FN₂O₃
Molecular Weight:422.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Neuroinflammatory-IN-2 Chemical Structure

CAS No.: 2361384-14-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

MAO-B

10.30 μM (IC₅₀)

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

In Vitro

Neuroinflammatory-IN-2 (compound 7i) (1 and 10 μM) dramatically increases the viability of H₂O₂-treated PC-12 cells by 70.2% and 81.6% at 1 and 10 μM, respectively^[1].
Neuroinflammatory-IN-2 (0.5, 2.5 and 10.0 μM) inhibits NO expression in LPS-stimulated BV-2 cells by 32.4%, 46.7% and 57.2% at the concentration of 0.5, 2.5 and 10.0 μM respectively; and inhibits TNF-α by 35.8%, 53.1% and 76.5%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2361384-14-5
Molecular Weight 422.49
Formula C₂₅H₂₇FN₂O₃
SMILES

CC(C1=CC=C(C2=CC=C(NCC3=CC(N(C)C)=CC=C3O)C=C2)C(F)=C1)C(OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang Z, et al. Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease. Bioorg Med Chem. 2020 Apr 1;28(7):115374. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Neuroinflammatory-IN-2

All Monoamine Oxidase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Neuroinflammatory-IN-2 Related Classifications

HY-150563 Related Classifications