2361384-14-5
Chemical Structure
Neuroinflammatory-IN-2
- CAS No.: 2361384-14-5
- Formula:C25H27FN2O3
- Molecular Weight:422.49
IUPAC Name: methyl 2-(4'-((5-(dimethylamino)-2-hydroxybenzyl)amino)-2-fluoro-[1,1'-biphenyl]-4-yl)propanoate
InChIKey: WQZSREHRZGCVEW-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(C2=CC=C(NCC3=CC(N(C)C)=CC=C3O)C=C2)C(F)=C1)C(OC)=O
Biological Activity: Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease[1].
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Neuroinflammatory-IN-2 | Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease. | |||||||||||||||||||||
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Keywords
