2. Immunology/Inflammation
  3. MHC
  4. MC38 SLP Adpgk

MC38 SLP Adpgk  (Synonyms: Adpgk peptide)

Cat. No.: HY-P11060 Purity: 97.52%
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MC38 SLP Adpgk (Adpgk peptide) is an H-2 Kb-restricted colorectal cancer neoantigen peptide. MC38 SLP Adpgk is formulated into PCNP nanocomplexes together with CpG ODN. PCNP vaccines significantly enhance the co-delivery efficiency of neoantigens and adjuvants to lymphoid organs, and activate cytotoxic T cells. PCNP vaccines not only protect mice from MC-38 colorectal tumor invasion, but also exhibit anti-tumor efficacy in established colorectal tumor models and significantly prolong the survival of tumor-bearing mice.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MC38 SLP Adpgk

MC38 SLP Adpgk Chemical Structure

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Based on 1 publication(s) in Google Scholar

MC38 SLP Adpgk Related Antibodies

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MHC I MHC II

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Description

MC38 SLP Adpgk (Adpgk peptide) is an H-2 Kb-restricted colorectal cancer neoantigen peptide. MC38 SLP Adpgk is formulated into PCNP nanocomplexes together with CpG ODN. PCNP vaccines significantly enhance the co-delivery efficiency of neoantigens and adjuvants to lymphoid organs, and activate cytotoxic T cells. PCNP vaccines not only protect mice from MC-38 colorectal tumor invasion, but also exhibit anti-tumor efficacy in established colorectal tumor models and significantly prolong the survival of tumor-bearing mice[1].

IC50 & Target[1]

MHC I

 

In Vitro

MC38 SLP Adpgk (5 µg/mL; 1.5 h) stimulates naive murine splenocytes to generate peptide-pulsed cells suitable for labeling with CFSE[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC38 SLP Adpgk Related Antibodies
Molecular Weight

2912.41

Formula

C128H207N33O38S3
Appearance

Solid

Color

White to light yellow

Sequence

Gly-Ile-Pro-Val-His-Leu-Glu-Leu-Ala-Ser-Met-Thr-Asn-Met-Glu-Leu-Met-Ser-Ser-Ile-Val-His-Gln-Gln-Val-Phe
Sequence Shortening

GIPVHLELASMTNMELMSSIVHQQVF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (0.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Purity & Documentation
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MC38 SLP Adpgk Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC38 SLP AdpgkAdpgk peptideMHCMajor Histocompatibility Complexmurine splenocytescolon cancermurine BMDCslymphoid organsdendritic cellcolorectal cancerMC-38 colon carcinomaRAW264.7 macrophage cellscytotoxic T cellsADP-dependent glucokinaseInhibitorinhibitorinhibit

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