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  3. Fluorescent Dye
  4. IR-990

IR-990 is an activatable NIR-II fluorescent probe with an acceptor-π-acceptor (A-π-A) skeleton for real-time detection of H2O2 in vivo. IR-990 is a powerful diagnosis of agent-induced liver injury (DILI).

For research use only. We do not sell to patients.

IR-990 Chemical Structure

IR-990 Chemical Structure

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IR-990 Related Antibodies

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Description

IR-990 is an activatable NIR-II fluorescent probe with an acceptor-π-acceptor (A-π-A) skeleton for real-time detection of H2O2 in vivo. IR-990 is a powerful diagnosis of agent-induced liver injury (DILI)[1].

In Vitro

IR-990 (0-30 μM) treatment shows high cell viability[1].
IR-990 (10 μM; 1 h) can sensitively visualize endogenous H2O2 levels in cells, and possess excellent ability to detect H2O2 in the cell model of acetaminophen-induced liver injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IR-990 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HeLa and HepG2 cells
Concentration: 0-30 μM
Incubation Time:
Result: Observed high cell viability after the cells treated with different concentrations of IR-990.

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 10 μM
Incubation Time: 1 hour
Result: Observed NIR-II fluorescence with 1.7-fold fluorescence enhancement, when the cells were pretreated with different concentrations of lipopolysaccharide (50-100 μM).

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 10 μM
Incubation Time: 1 hour
Result: Exhibited higher NIR-II fluorescence intensity when pretreated with acetaminophen, resulting in remarkable fluorescence enhancement up to 8.5-fold.
In Vivo

IR-990 (intravenous injection; 195.31 μg per mouse; once) is a powerful tool for real-time detection of H2O2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (6−8 weeks old, 18−20 g) with acetaminophen-induced liver injury[1]
Dosage: 195.31 μg per mouse
Administration: Intravenous injection; 195.31 μg per mouse; once
Result: Observed NIR-II fluorescence after 20 min for the acetaminophen-treated group, exhibiting the highest fluorescence intensity at 1 h postinjection and a high signal-to-background ratio up to 11.3/1.
Molecular Weight

976.53

Formula

C49H47BI2N2O3
SMILES

CC1(C)OB(C2=CC=C(COC(C=CC(/C=C/C3=[N+](C4=CC=CC5=C4C3=CC=C5)CC)=C6)=C6/C=C/C7=[N+](C8=C9C7=CC=CC9=CC=C8)CC)C=C2)OC1(C)C.[I-].[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IR-990 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IR-990IR990IR 990Fluorescent Dyeacceptor-π-acceptorA-π-Adiagnosisdrug-induced liver injuryDILIHeLaHepG2Inhibitorinhibitorinhibit

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HY-151109
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