IR-990
IR-990 is an activatable NIR-II fluorescent probe with an acceptor-π-acceptor (A-π-A) skeleton for real-time detection of H2O2 in vivo. IR-990 is a powerful diagnosis of agent-induced liver injury (DILI).
For research use only. We do not sell to patients.
- Formula: C49H47BI2N2O3
- Molecular Weight:976.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IR-990 (0-30 μM) treatment shows high cell viability[1].
IR-990 (10 μM; 1 h) can sensitively visualize endogenous H2O2 levels in cells, and possess excellent ability to detect H2O2 in the cell model of acetaminophen-induced liver injury[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa and HepG2 cells
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Concentration:0-30 μM
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Incubation Time:
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Result:Observed high cell viability after the cells treated with different concentrations of IR-990.
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Cell Line:HeLa cells
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Concentration:10 μM
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Incubation Time:1 hour
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Result:Observed NIR-II fluorescence with 1.7-fold fluorescence enhancement, when the cells were pretreated with different concentrations of lipopolysaccharide (50-100 μM).
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Cell Line:HeLa cells
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Concentration:10 μM
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Incubation Time:1 hour
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Result:Exhibited higher NIR-II fluorescence intensity when pretreated with acetaminophen, resulting in remarkable fluorescence enhancement up to 8.5-fold.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice (6−8 weeks old, 18−20 g) with acetaminophen-induced liver injury[1]
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Dosage:195.31 μg per mouse
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Administration:Intravenous injection; 195.31 μg per mouse; once
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Result:Observed NIR-II fluorescence after 20 min for the acetaminophen-treated group, exhibiting the highest fluorescence intensity at 1 h postinjection and a high signal-to-background ratio up to 11.3/1.
Chemical Information
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Molecular Weight 976.53
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Formula C49H47BI2N2O3
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SMILES
CC1(C)OB(C2=CC=C(COC(C=CC(/C=C/C3=[N+](C4=CC=CC5=C4C3=CC=C5)CC)=C6)=C6/C=C/C7=[N+](C8=C9C7=CC=CC9=CC=C8)CC)C=C2)OC1(C)C.[I-].[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IR-990 Related Classifications
HY-151109 Related Classifications
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