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GSK 366 

Cat. No.: HY-119171 Purity: 99.81%
Handling Instructions

GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50s of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO), respectively.

For research use only. We do not sell to patients.

GSK 366 Chemical Structure

GSK 366 Chemical Structure

CAS No. : 1953157-39-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 780 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50s of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO), respectively[1].

IC50 & Target

IC50: 2.3 nM (human KMO), 0.7 nM (Pf-KMO)[1]

Molecular Weight

361.78

Formula

C₁₇H₁₆ClN₃O₄

CAS No.

1953157-39-5

SMILES

O=C(O)CCC1=NOC2=C1C=C(Cl)C(O[[email protected]@H](C3=NN=C(C)C=C3)C)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (691.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7641 mL 13.8206 mL 27.6411 mL
5 mM 0.5528 mL 2.7641 mL 5.5282 mL
10 mM 0.2764 mL 1.3821 mL 2.7641 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.75 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.75 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

GSK 366GSK366GSK-366OthersInhibitorinhibitorinhibit

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Product Name:
GSK 366
Cat. No.:
HY-119171
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